CDC23

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The protein Cell division cycle 23 homolog (S. cerevisiae) , also CDC23 , is encoded by the CDC23 gene .

function

The human protein CDC23 is very similar to its homologue Cdc23 in S. cerevisiae . The molecule is essential for the cell cycle to proceed through the G2-M damage control point . The protein is part of the anaphase promoting complex (APC), which consists of 8 protein subunits and is highly conserved in eukaryotic cells. APC catalyzes the formation of the cyclin B - ubiquitin conjugate , which causes the ubiquitin-controlled proteolysis of cyclin B. Like three other components of the APC complex, the protein contains the TPR - structural motif as a protein-protein interaction domain .

Interactions

CDC23 has been shown to interact with CDC27 .

literature

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  • Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW: Identification of a cullin homology region in a subunit of the anaphase-promoting complex . In: Science . 279, No. 5354, February 1998, pp. 1219-22. doi : 10.1126 / science.279.5354.1219 . PMID 9469815 .
  • Zhao N, Lai F, Fernald AA, Eisenbart JD, Espinosa R, Wang PW, Le Beau MM: Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias . In: Genomics . 53, No. 2, October 1998, pp. 184-90. doi : 10.1006 / geno.1998.5473 . PMID 9790767 .
  • Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM: Characterization of the DOC1 / APC10 subunit of the yeast and the human anaphase-promoting complex . In: The Journal of Biological Chemistry . 274, No. 20, May 1999, pp. 14500-7. doi : 10.1074 / jbc.274.20.14500 . PMID 10318877 .
  • Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM: Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons . In: Proceedings of the National Academy of Sciences of the United States of America . 96, No. 20, September 1999, pp. 11317-22. doi : 10.1073 / pnas.96.20.11317 . PMID 10500174 . PMC 18031 (free full text).
  • Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM: The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex . In: Proceedings of the National Academy of Sciences of the United States of America . 97, No. 16, August 2000, pp. 8973-8. doi : 10.1073 / pnas.97.16.8973 . PMID 10922056 . PMC 16806 (free full text).
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  • Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T, Navarro C, Puisieux A: Alterations of anaphase-promoting complex genes in human colon cancer cells . In: Oncogene . 22, No. 10, March 2003, pp. 1486-90. doi : 10.1038 / sj.onc.1206224 . PMID 12629511 .
  • Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM: TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 . In: Current Biology . 13, No. 17, September 2003, pp. 1459-68. doi : 10.1016 / S0960-9822 (03) 00581-5 . PMID 12956947 .
  • Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM: Mitotic regulation of the human anaphase-promoting complex by phosphorylation . In: The EMBO Journal . 22, No. 24, December 2003, pp. 6598-609. doi : 10.1093 / emboj / cdg627 . PMID 14657031 . PMC 291822 (free full text).
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP: Large-scale characterization of HeLa cell nuclear phosphoproteins . In: Proceedings of the National Academy of Sciences of the United States of America . 101, No. 33, August 2004, pp. 12130-5. doi : 10.1073 / pnas.0404720101 . PMID 15302935 . PMC 514446 (free full text).
  • Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP: Phosphoproteomic analysis of the developing mouse brain . In: Molecular & Cellular Proteomics . 3, No. 11, November 2004, pp. 1093-101. doi : 10.1074 / mcp.M400085-MCP200 . PMID 15345747 .
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  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R: Phosphoproteome analysis of the human mitotic spindle . In: Proceedings of the National Academy of Sciences of the United States of America . 103, No. 14, April 2006, pp. 5391-6. doi : 10.1073 / pnas.0507066103 . PMID 16565220 . PMC 1459365 (free full text).
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP: A probability-based approach for high-throughput protein phosphorylation analysis and site localization . In: Nature Biotechnology . 24, No. 10, October 2006, pp. 1285-92. doi : 10.1038 / nbt1240 . PMID 16964243 .
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . In: Cell . 127, No. 3, November 2006, pp. 635-48. doi : 10.1016 / j.cell.2006.09.026 . PMID 17081983 .

Individual evidence

  1. ↑ a b Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae) .
  2. ↑ Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM: TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 . In: Current Biology . 13, No. 17, September 2003, pp. 1459-68. doi : 10.1016 / S0960-9822 (03) 00581-5 . PMID 12956947 .
  3. ↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM: The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex . In: Proceedings of the National Academy of Sciences of the United States of America . 97, No. 16, August 2000, pp. 8973-8. doi : 10.1073 / pnas.97.16.8973 . PMID 10922056 . PMC 16806 (free full text).