Casomorphine
Casomorphins are peptides that are produced during the digestion of milk proteins ( exorphins ). Certain members of this group of substances can have an analgesic effect. However, studies have not been able to determine whether intact casomorphine molecules are absorbed via the intestine or whether they are transported across the blood-brain barrier .
In cancer research , its analgesic effect is being investigated. It is also said to have antihypertensive effects.
If absorbed intact, they would have an effect similar to exogenous opioids if they would bind to specific opioid receptors :
- Inhibition of intestinal peristalsis (involuntary intrinsic mobility).
- Inhibition of the secretion of electrolytes with simultaneous promotion of the uptake ( absorption ) of electrolytes.
literature
- Kurek M, Przybilla B, Hermann K, Ring J: A naturally occurring opioid peptide from cow's milk, beta-casomorphine-7, is a direct histamine releaser in man . In: International Archives of Allergy and Immunology . 97, No. 2, 1992, pp. 115-20. PMID 1374738 .
- Jinsmaa Y, Yoshikawa M: Enzymatic release of neocasomorphin and beta-casomorphin from bovine beta-casein . In: Peptides . 20, No. 8, 1999, pp. 957-62. PMID 10503774 .
Individual evidence
- ^ European Food Safety Authority. February 1, 2009 Review of the potential health impact of β-casomorphins and related peptides