Chandler Syndrome

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Classification according to ICD-10
H21.2 Degeneration of the iris and ciliary body
ICD-10 online (WHO version 2019)

The Chandler's syndrome is a very rare form of iridocorneal endothelial syndrome with the main features in adolescents occur, unilateral atrophy , color change and nodule formation of the iris and corneal dystrophy .

Synonym : English iris atrophy with corneal edema and glaucoma

The name refers to the author of the first description from 1956 by the American ophthalmologist Paul A. Chandler.

distribution

The frequency and cause are unknown. It is the most common form of iridocorneal endothelial syndrome.

Clinical manifestations

Clinical criteria are:

  • especially in female adolescents
  • unilateral corneal edema with corneal endothelial dystrophy
  • Iris atrophy with only a small number of iris anomalies
  • Glaucoma on the affected side only

Differential diagnosis

The other forms of the iridocorneal endothelial syndrome must be distinguished.

In Cogan-Reese syndrome, secondary glaucoma is usually weaker, but corneal edema is usually more pronounced.

literature

  • GD Kymionis, GA Kontadakis, GI Agorogiannis, M. Bennett, F. Angelidou: Descemet stripping automated endothelial keratoplasty combined with phacoemulsification in Chandler syndrome. In: European journal of ophthalmology. Volume 21, number 4, 2011 Jul – Aug, pp. 495–497, doi: 10.5301 / EJO.2010.6210 , PMID 21218389 .
  • MC Mocan, B. Bozkurt, M. Orhan, M. Irkec: Chandler syndrome manifesting as ectropion uvea following laser in situ keratomileusis. In: Journal of cataract and refractive surgery. Volume 34, Number 5, May 2008, pp. 871-873, doi: 10.1016 / j.jcrs.2007.12.047 , PMID 18471650 .
  • JD Sheppard, FA Lattanzio, PB Williams, PV Mitrev, RC Allen: Confocal microscopy used as the definitive, early diagnostic method in Chandler syndrome. In: Cornea. Volume 24, Number 2, March 2005, pp. 227-229, PMID 15725894 .
  • C. Lammerhuber, G. Bartl: The Chandler Syndrome - a case demonstration. In: Clinical monthly sheets for ophthalmology. Volume 189, Number 5, November 1986, pp. 413-415, doi: 10.1055 / s-2008-1050843 , PMID 3492627 .

Individual evidence

  1. ↑ a b Bernfried Leiber (founder): The clinical syndromes. Syndromes, sequences and symptom complexes . Ed .: G. Burg, J. Kunze, D. Pongratz, PG Scheurlen, A. Schinzel, J. Spranger. 7., completely reworked. Edition. tape 2 : symptoms . Urban & Schwarzenberg, Munich et al. 1990, ISBN 3-541-01727-9 .
  2. ↑ a b c d Chandler syndrome. In: Orphanet (Rare Disease Database).
  3. ^ PA Chandler: Atrophy of the stroma of the iris; endothelial dystrophy, corneal edema, and glaucoma. In: American journal of ophthalmology. Volume 41, Number 4, April 1956, pp. 607-615, PMID 13302362 .

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