Cogan-Reese Syndrome

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Classification according to ICD-10
H21.2 Degeneration of the iris and ciliary body
ICD-10 online (WHO version 2019)

The Cogan-Reese syndrome is a very rare form of iridocorneal endothelial syndrome with the main features of atrophy , color change and nodule formation of the iris and corneal dystrophy .

Synonyms are: nevus iridis syndrome; Iris nevus syndrome; English NUDE syndrome (nodular, unilateral galucoma, Descemet's membrane, endothelial)

The name refers to the first authors of the description from 1969 by the American ophthalmologists David Glendering Cogan (1908-1993) and Algernon B. Reese (1896-1981).

The first description probably comes from Berta A. Klien in 1941.

distribution

The frequency and cause are unknown.

Clinical manifestations

Clinical criteria are:

  • Iris heterochromia (brown heterochromia) with numerous pigmented cell nests on the anterior surface of the iris
  • droplet-shaped deposits (cornea guttata)
  • unilateral glaucoma
  • Corneal edema
  • Ectopy of the pupil and uvea
  • sector-shaped atrophy
  • peripheral anterior synechiae

Differential diagnosis

The other forms of the iridocorneal endothelial syndrome must be distinguished.

In Cogan-Reese syndrome, the iris atrophy is usually weaker, but glaucoma is usually more pronounced.

literature

  • B. Daicker, G. Sturrock, R. Guggenheim: On the knowledge of the Cogan-Reese syndrome. In: Clinical monthly sheets for ophthalmology. 180, 1982, p. 531, doi: 10.1055 / s-2008-1055140
  • P. Denis: Le glaucome du syndrome irido-cornéo-endothélial. In: Journal francais d'ophtalmologie. Volume 30, Number 2, February 2007, pp. 189-195, PMID 17318107 .

Individual evidence

  1. ↑ a b Bernfried Leiber (founder): The clinical syndromes. Syndromes, sequences and symptom complexes . Ed .: G. Burg, J. Kunze, D. Pongratz, PG Scheurlen, A. Schinzel, J. Spranger. 7., completely reworked. Edition. tape 2 : symptoms . Urban & Schwarzenberg, Munich et al. 1990, ISBN 3-541-01727-9 .
  2. ↑ a b Cogan-Reese syndrome. In: Orphanet (Rare Disease Database).
  3. ^ DG Cogan, AB Reese: A syndrome of iris nodules, ectopic Descemets membrane, and unilateral glaucoma. In: Documenta Ophtalmologica , Den Haag, 1969, Vol. 26, pp. 424-433.
  4. ↑ Who named it
  5. ^ BA Klien: Pseudomelanomas of the iris. in: American journal of ophthalmology , Vol. 24, 1941, pp. 133-138.
  6. ^ American Academy of Ophthalmology

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