Checkpoint (cell biology)

from Wikipedia, the free encyclopedia

In cell biology, the term checkpoint denotes a control point - as well as the control mechanism behind it - that regulates the chronological sequence of cell cycle processes .

properties

The activation of cell cycle checkpoints was originally described as a response to specific cellular malfunctions, but it is now widely accepted that checkpoints are an integral part of physiological cell cycle processes.

The mitotic checkpoint (also known as spindle checkpoint ) is a mechanism that coordinates the timing of mitosis with the attachment of the kinetochore to the mitotic spindle apparatus .

See also

Individual evidence

  1. ↑ KM Yasutis, KG Kozminski: Cell cycle checkpoint regulators reach a zillion. In: Cell cycle (Georgetown, Tex.). Volume 12, Number 10, May 2013, pp. 1501-1509, ISSN  1551-4005 . doi : 10.4161 / cc.24637 . PMID 23598718 . PMC 3680530 (free full text).
  2. ↑ L. Jia, S. Kim, H. Yu: Tracking spindle checkpoint signals from kinetochores to APC / C. In: Trends in Biochemical Sciences . Volume 38, Number 6, June 2013, pp. 302-311, ISSN  0968-0004 . doi : 10.1016 / j.tibs.2013.03.004 . PMID 23598156 .