Clutton Syndrome

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Classification according to ICD-10
A50.5 Other forms of florid late congenital syphilis
M03.1- * Post-infectious arthritis in syphilis
Includes: Clutton syndrome (A50.5 † M03.1- *)
ICD-10 online (WHO version 2019)

The Clutton syndrome , also known as Clutton hydrarthrosis or syphilitic arthritis , is a symmetrical hydrarthrosis ( joint effusion ) of the large joints that occurs in childhood as a result of congenital syphilis ( syphilis , congenital syphilis) .

description

Clutton syndrome is characterized by effusions and swelling of the joints, as well as thickening of the synovial membrane ( stratum synoviale ) in the large joints, especially the knee joints . The Clutton syndrome always occurs on both sides (symmetrically). One speaks in this context of a Clutton-joint ( Engl. Clutton's joint ) This is a relatively late manifestation of congenital syphilis, which usually develops between the ages of 8 and 15 years.

therapy

Clutton syndrome is a manifestation of tertiary syphilis. The therapy is primarily aimed at combating syphilis. The Clutton joints, however, do not respond to antibiotic measures in this late phase of syphilis .

Initial description

Henry Hugh Clutton, first descriptor and namesake

The Clutton syndrome is named after the British surgeon Henry Hugh Clutton (1850-1909). In 1886 he was the first to recognize the connection between congenital syphilis and synovitis .

Individual evidence

  1. ^ JV Klauder and HF Robertson: Symmetrical serious synovitis (Clutton's joints). In: J Am Med Ass 103, 1934, pp. 236-240.
  2. ↑ W. Mohr: Joint pathology: Historical bases, causes and developments of. Verlag Springer, 2000, ISBN 3-540-65971-4 limited preview in the Google book search
  3. ^ TR Harrison et al: Harrison's rheumatology. McGraw-Hill Professional, 2006, ISBN 0-071-45743-7 limited preview in Google Book Search
  4. ↑ K. Wicher and V. Wicher: Immunopathology of syphilis. In: Pathogenesis and Immunology of Treponemal Infection. RF Schell and DM Muscher (Editors), Marcel Dekker Inc, 1983, ISBN 0-824-71384-2 , pp. 139-160.
  5. ↑ AV Kuznetsov: Molecular detection of Treponema pallidum using the polymerase chain reaction (PCR) and hybridization in various samples from patients with syphilis. Dissertation, LMU Munich, 2007, DNB 985144866/34
  6. ^ HH Clutton: Symmetrical Synovitis of the Knee in Hereditary Syphilis. In: The Lancet 1886, pp. 391-393. PMID 5669866 (re-print)
  7. ^ WR bed: Henry Hugh Clutton (1850-1909), a centennial note. In: Proc R Soc Med 44, 1951, pp. 71-72. PMID 14808232 , PMC 2081607 (free full text)

literature