Crooke cell
Numerous Crooke cells in a so-called Crooke cell adenoma . Hematoxylin-eosin stain . 400x
Characteristic perinuclear expression of cytokeratin. Immunohistochemistry . 400x
As Crooke cells are hyalinized basophils of adenohypophysis referred to by the British endocrinologist Arthur Carleton Crooke described (1905-1990) for the first time. The ring-shaped storage of cytokeratins is also characteristic .
Crooke cells represent secondary regressive changes in ACTH- producing cells of the adenohypophysis in hypercortisolism and are typically observed in Cushing's syndrome , but also in non-neoplastic adenohypophyseal tissue after drug administration of cortisone.
The so-called Crooke cell adenoma , a rare variant of the ACTH cell adenoma , whose tumor cells have the morphology of Crooke cells, must be distinguished from this .
Individual evidence
- ↑ Crooke: A change in the basophile cells of the pituitary gland common to conditions which exhibit the syndrome attributed to basophile adenoma. J Pathol 1935; 41: 339-349.
- ↑ a b George et al .: Crooke's cell adenoma of the pituitary: an aggressive variant of corticotroph adenoma. At J Surg Pathol . 2003 Oct; 27 (10): 1330-6. PMID 14508394
- ↑ Eschbacher & Coons: Cytokeratin CK20 is a sensitive marker for Crooke's cells and the early cytoskeletal changes associated with hypercortisolism within pituitary corticotrophs. Endocr Pathol. 2006; 17 (4): 365-76. PMID 17525485