Cytoplasmic hybrid

A cytoplasmic hybrid or abbreviated Zybrid ( English Cybrid ) is a living cell , its nucleus removed and replaced with the nucleus of another (animal) nature has been replaced (by somatic cell nuclear transfer ). There is therefore a hybridization at the cellular level, which creates a chimera . The chromosomal and cytoplasmic hereditary material (the Barr bodies ) come from different species. The cybrid cell can be capable of multiplying. A development into an organism has not yet been observed. The process of creating cytoplasmic hybrids is bioethically controversial.

Cytoplasmic hybrids with animal cell nuclei are used to examine genetic defects in human mitochondria , among other things to examine whether they are involved in the development of certain tumors .

Individual evidence

↑ P. Narbonne, K. Miyamoto, JB Gurdon: Reprogramming and development in nuclear transfer embryos and in interspecific systems. In: Current opinion in genetics & development. Volume 22, number 5, October 2012, ISSN 1879-0380 , pp. 450–458, doi: 10.1016 / j.gde.2012.09.002 , PMID 23062626 , PMC 3654497 (free full text).
^ HM Wilkins, SM Carl, RH Swerdlow: Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies. In: Redox biology. [Electronic publication before printing] April 2014, ISSN 2213-2317 , doi: 10.1016 / j.redox.2014.03.006 , PMID 25460729 , PMC 4297942 (free full text).
↑ MP Bayona-Bafaluy, E. Lopez-Gallardo, J. Montoya, E. Ruiz-Pesini: maternally inherited susceptibility to cancer. In: Biochimica et Biophysica Acta . Volume 1807, number 6, June 2011, ISSN 0006-3002 , pp. 643-649, doi: 10.1016 / j.bbabio.2010.08.004 , PMID 20732295 .

[1] P. Narbonne, K. Miyamoto, JB Gurdon: Reprogramming and development in nuclear transfer embryos and in interspecific systems. In: Current opinion in genetics & development. Volume 22, number 5, October 2012, ISSN 1879-0380 , pp. 450–458, doi: 10.1016 / j.gde.2012.09.002 , PMID 23062626 , PMC 3654497 (free full text).

[2] HM Wilkins, SM Carl, RH Swerdlow: Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies. In: Redox biology. [Electronic publication before printing] April 2014, ISSN 2213-2317 , doi: 10.1016 / j.redox.2014.03.006 , PMID 25460729 , PMC 4297942 (free full text).

[3] MP Bayona-Bafaluy, E. Lopez-Gallardo, J. Montoya, E. Ruiz-Pesini: maternally inherited susceptibility to cancer. In: Biochimica et Biophysica Acta . Volume 1807, number 6, June 2011, ISSN 0006-3002 , pp. 643-649, doi: 10.1016 / j.bbabio.2010.08.004 , PMID 20732295 .