Homeobox protein DLX-6

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DLX6
DLX6
Gene expression pattern of the DLX6 gene

The homeobox protein DLX6 is a protein for which the existing in people DLX6 - gene coded.

The gene codes as a member of the homeobox transcription factor gene family, which are very similar to the “distal-less” genes of Drosophila . The gene family has at least six members that code for proteins that play a role in the forebrain and the development of the facial skull . The gene is in a configuration with other members of the gene family on the long arm of chromosome 7 .

Individual evidence

  1. ↑ Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al .: Cloning and characterization of two members of the vertebrate Dlx gene family . In: Proc Natl Acad Sci USA . 91, No. 6, April 1994, pp. 2250-2254. doi : 10.1073 / pnas.91.6.2250 . PMID 7907794 . PMC 43348 (free full text).
  2. ↑ a b Entrez Gene: DLX6 distal-less homeobox 6 . Retrieved May 20, 2012.

literature

  • Crackower MA, Scherer SW, Rommens JM, et al. : Characterization of the split hand / split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. . In: Hum. Mol. Genet. . 5, No. 5, 1997, pp. 571-579. doi : 10.1093 / hmg / 5.5.571 . PMID 8733122 .
  • Charité J, McFadden DG, Merlo G, et al. : Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer. . In: Genes Dev. . 15, No. 22, 2001, pp. 3039-3049. doi : 10.1101 / gad.931701 . PMID 11711438 . PMC 312822 (free full text).
  • Depew MJ, Lufkin T, Rubenstein JL: Specification of jaw subdivisions by Dlx genes. . In: Science . 298, No. 5592, 2002, pp. 381-385. doi : 10.1126 / science.1075703 . PMID 12193642 .
  • Strausberg RL, Feingold EA, Grouse LH, et al. : Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . In: Proc. Natl. Acad. Sci. USA . 99, No. 26, 2003, pp. 16899-16903. doi : 10.1073 / pnas.242603899 . PMID 12477932 . PMC 139241 (free full text).
  • Nabi R, Zhong H, Serajee FJ, Huq AH: No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism. . In: Am. J. Med. Genet. B Neuropsychiatr. Genet. . 119, No. 1, 2004, pp. 98-101. doi : 10.1002 / ajmg.b.10012 . PMID 12707945 .
  • Hillier LW, Fulton RS, Fulton LA, et al. : The DNA sequence of human chromosome 7 . In: Nature . 424, No. 6945, 2003, pp. 157-164. doi : 10.1038 / nature01782 . PMID 12853948 .
  • Ota T, Suzuki Y, Nishikawa T, et al. : Complete sequencing and characterization of 21,243 full-length human cDNAs. . In: Nat. Genet. . 36, No. 1, 2004, pp. 40-45. doi : 10.1038 / ng1285 . PMID 14702039 .
  • Gerhard DS, Wagner L, Feingold EA, et al. : The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . In: Genome Res. . 14, No. 10B, 2004, pp. 2121-2127. doi : 10.1101 / gr.2596504 . PMID 15489334 . PMC 528928 (free full text).
  • Schüle B, Li HH, Fisch-Kohl C, et al. : DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency. . In: Am. J. Hum. Genet. . 81, No. 3, 2007, pp. 492-506. doi : 10.1086 / 520063 . PMID 17701895 . PMC 1950824 (free full text).