Decarboxylases
| Decarboxylases | ||
|---|---|---|
| Enzyme classification | ||
| EC, category | 4.1.1.- , lyase | |
Decarboxylases are enzymes that catalyze the splitting off of a carboxy group (-COOH) from organic acids . In the degradation process, CO 2 is an end product.
For example, a decarboxylase is very often required to break down α-keto acids (e.g. pyruvic acid with pyruvate dehydrogenase or pyruvate decarboxylase ). Thiamine pyrophosphate (diphosphoric acid ester of vitamin B1 ) is found in many decarboxylases as a coenzyme and is bound in these as a prosthetic group .
In contrast, carboxylases are enzymes that build carbon dioxide into their substrate .
See also
Individual evidence
- ↑ decarboxylases. In: Lexicon of Biology . Spektrum.de , 1999, accessed on June 20, 2020 .
- ^ Albert Gossauer: Structure and reactivity of biomolecules , Verlag Helvetica Chimica Acta, Zurich, 2006, p. 450, ISBN 978-3-906390-29-1 .