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Enzyme classification
EC, category 6.4.1. Ligase

Carboxylases are enzymes that incorporate carbon dioxide as a carboxy group into their substrate . The process they catalyze is called carboxylation . The process is ATP- dependent. You have biotin as a prosthetic group . Carboxylases ( EC  6.4.1.- ) mostly belong to the group of ligases .


The most common carboxylase is ribulose-1,5-bisphosphate carboxylase ( Rubisco ), an enzyme that binds carbon dioxide to ribulose-1,5-bisphosphate in the Calvin cycle of photosynthesis . Through this biochemical reaction, carbon dioxide is introduced from the water or from the air into the metabolism of photosynthesizing plants , protista or monera .

Other important carboxylases are:


The PEP carboxylase is an essential switching point in the plant metabolism .


The carboxylase was discovered by the biochemist Carl Neuberg .

Other classes of enzymes

Enzymes that, unlike carboxylases, release carbon dioxide from their substrates are called decarboxylases .

Web links

Individual evidence

  1. a b Florian Horn: Biochemistry of humans. The textbook for medical studies. 5th edition. Thieme, 2012, ISBN 978-3-13-130885-6 , p. 73 .