Depurination

The depurination is a DNA damage in which a purine base , that is either adenine or guanine , sugar phosphate backbone of the DNA double strand by the hydrolysis is cleaved. The phosphodiester structure of the DNA remains intact during depurination, but single strand breaks in a DNA strand can occur as a result of the depurination . The remaining apurine position can remain free or be replaced by another identical or non-identical base. The depurination takes place mainly at high heat and in an acidic environment. In the course of the base excision repair , the errors that have arisen can be eliminated again.

Web links

Learning unit: DNA damage deamination at Chemgapedia

Individual evidence

↑ Genetics: General Genetics - Molecular Genetics - Developmental Genetics . Georg Thieme Verlag, 2008, ISBN 978-3-13-151422-6 , p. 500 ( books.google.de ).
↑ Tomas Lindahl, Barbro Nyberg: Rate of depurination of native deoxyribonucleic acid. In: Biochemistry. 11, 1972, p. 3610, doi : 10.1021 / bi00769a018 .
^ NCBI Bookshelf: DNA Repair - Molecular Biology of the Cell , accessed February 17, 2017

[1] Genetics: General Genetics - Molecular Genetics - Developmental Genetics . Georg Thieme Verlag, 2008, ISBN 978-3-13-151422-6 , p. 500 ( books.google.de ).

[DOI10.1021/bi00769a018-2] Tomas Lindahl, Barbro Nyberg: Rate of depurination of native deoxyribonucleic acid. In: Biochemistry. 11, 1972, p. 3610, doi : 10.1021 / bi00769a018 .

[ncbi.nlm.nih.gov-3] NCBI Bookshelf: DNA Repair - Molecular Biology of the Cell , accessed February 17, 2017