German Childhood Cancer Registry

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The German Childhood Cancer Register (DKKR) has been located at the Institute for Medical Biometry, Epidemiology and Computer Science (IMBEI) at the University Medical Center of Johannes Gutenberg University Mainz since it was founded in 1980 . The previous directors are Jörg Michaelis (1980–2001) and Peter Kaatsch (2001–2019). It records cancer cases in children and adolescents under 18 years of age (under 15 years of age until 2008) nationwide for all of Germany (since 1991 also for the new federal states). In the period from 1980 to 2017, diseases of over 64,000 patients were recorded in this register. An entry is only made if the parties concerned agree.

The completeness of the registration is about 95% for the whole of Germany and corresponds to the international requirements for epidemiological cancer registries. The DKKR is a member of the International Association of Cancer Registries (IACR) and the European Network of Cancer Registries (ENCR).

Every year around 2,200 patients under the age of 18 are reported from the pediatric-oncological facilities that are part of the Society for Pediatric Oncology and Hematology (GPOH). A closely interlinked information network exists with the GPOH study groups. The database at the DKKR provides a suitable basis for recognizing possible temporal trends and regional clusters and for carrying out epidemiological studies. The importance of the examinations carried out at the German Childhood Cancer Registry is that the results are representative for Germany due to the extensive data material and the large number of them. The area coverage allows further regional inquiries to be answered about possible cancer clusters. With the diagnostic and therapeutic advances achieved in the last few decades, the investigation and avoidance of possible long-term effects are becoming increasingly important. The German Childhood Cancer Register makes important contributions to this by intensifying long-term follow-up and z. B. the detection of secondary tumors performed.

The German Children's Cancer Register is funded by the federal and state health ministries. The way in which the register works, the legal basis, the methods used, the results of routine evaluations and key topics are available in the annual reports. An overview of the most important results is summarized in the 2018 annual report

Important studies

The German Childhood Cancer Registry has carried out three “nuclear power plant studies” (published in 1992, 1998 and 2008); the last one was the so-called KiKK study. Other larger studies dealt with the possible introduction of newborn screening for neuroblastoma, with possible causes of cancer development in children in general, or with secondary tumors as a result of cancer therapy. International collaborations include a. Participation in ACCIS and EUROCARE or the management of EU-funded studies on the long-term effects of childhood cancer treatment

Sensational publications by the DKKR

  • The epidemiological study of childhood cancer in the vicinity of nuclear power plants (KiKK study). This study comes to the conclusion that the incidence of cancer in children in the vicinity of German nuclear power plants has increased by approx. 50%. The authors were unable to identify any other cause (confounder) apart from the "distance" factor, but do not consider radioactive emissions to be the cause of the increased risk. The radioactive particles ingested through food and water from agricultural production in the area are not taken into account. The KiKK study is so important because it is not an ecological study, but a case-control study in which a group of sick people ("cases") does not match a statistically representative comparison group ("controls") - Sick people are compared with regard to the precise distance between their home and the nearest nuclear power plant. This significantly increases the informative value of the study compared to ecological studies. On February 23, 2010, in the report “Die Atomlüge” on NDR television, doubts were expressed about the neutrality of the management of the cancer registry. The first preliminary study of the KiKK study examined data from 1980 to 1995 on the basis of incidence rates. Their result was: no increased cancer rates in children under 15 years of age within a radius of 15 kilometers from the nuclear power plants. In addition, there was a threefold increase in the rate of leukemia among small children under five years of age in the five-kilometer vicinity of nuclear facilities. A second study by the IMSD followed five years later. The result: no increased risk of leukemia for children in the vicinity of nuclear power plants. According to the Munich physicist Alfred Körblein , the authors had changed the method so that in the end everything was "in the green". The institute made z. B. statistical calculations about the leukemia cluster Elbmarsch .

See also

Individual evidence

  1. ↑ International Association of Cancer Registries. Retrieved November 27, 2019 .
  2. ^ European Network of Cancer Registries. Retrieved November 27, 2019 .
  3. ^ Society for Pediatric Oncology and Hematology. Retrieved November 29, 2019 .
  4. ↑ Annual reports of the DKKR. Retrieved November 27, 2019 .
  5. ↑ Main results from the 2018 annual report. Accessed October 2, 2019 .
  6. ^ Kaatsch P, Spix C, Schulze-Rath R, Schmiedel S, Blettner M. Leukemia in young children living in the vicinity of German nuclear power plants. Int J Cancer 122, 721-726, 2008. PMID 18067131 doi: 10.1002 / ijc.23330
  7. ↑ Spix C, Schmiedel S, Kaatsch P, Schulze-Rath R, Blettner M. Case-control study on childhood cancer in the vicinity of nuclear power plants in Germany 1980-2003. Eur J Cancer 44, 275-284, 2008. PMID 18082395 doi: 10.1016 / j.ejca.2007.10.024
  8. ↑ Kaatsch P, Spix C, Jung I, Blettner M. Leukemia in children under 5 in the vicinity of German nuclear power plants. Deutsches Ärzteblatt Int 105 (42), 725–732, 2008. doi: 10.3238 / arztebl.2008.0725
  9. ↑ Spix C, Michaelis J, Berthold F, Erttmann R, Sander J, Schilling FH .: Lead-time and overdiagnosis estimation in neuroblastoma screening. Stat Med. 22, 2877-2892, 2003. PMID 12953286 doi: 10.1002 / sim.1533
  10. ↑ Kaatsch P. Environmental pollution and cancer risk in childhood. Monthly Pediatric Medicine Volume 165, pages 395–401, May 2017. Print ISSN 0026-9298, Online ISSN 1433-0474, doi: 10.1007 / s00112-017-0281-5
  11. ↑ Metayer C, Milne E, Clavel J, Infante-Rivard C, Petridou E, Taylor M, Schüz J, Spector LG, Dockerty JD, Magnani C, Pombo-de-Oliveira MS, Sinnett D, Murphy M, Roman E, Monge P, Ezzat S, Mueller BA, Scheurer ME, Armstrong BK, Birch J, Kaatsch P, Koifman S, Lightfoot T, Bhatti P, Bondy ML, Rudant J, O´Neill K, Miligi L, Dessypris N, Kang AY, Buffler PA. The Childhood Leukemia International Consortium. Cancer Epidemiol 37, 336-347, 2013. PMID 23403126 PMCID: PMC 3652629 (free full text) doi: 10.1016 / j.canep.2012.12.011
  12. ↑ Scholz-Kreisel P, Kaatsch P, Spix C, Schmidberger H, Marron M, Grabow D, Becker C, Blettner M. Second malignancies following childhood cancer treatment in Germany from 1980 to 2014 - a registry-based analysis. Deutsches Ärzteblatt Int 115, 385–392, 2018 PMID 29960606 PMCID: PMC 6041965 (free full text) doi: 10.3238 / arztebl.2018.0385
  13. ↑ Kaatsch P, Reinisch I, Spix C, Berthold F, Janka-Schaub G, Mergenthaler A, Michaelis J, Blettner M. Case control study on therapy of childhood cancer and occurrence of second malignant neoplasms in Germany. Cancer Causes Control 20, 956-980, 2009. PMID 19263232 doi: 10.1007 / s10552-009-9315-1
  14. ↑ ACCIS. Retrieved November 28, 2019 .
  15. ↑ EUROCARE. Retrieved November 28, 2019 .
  16. ↑ PanCareLIFE. Retrieved November 28, 2019 .
  17. ↑ PanCareSurFup. Retrieved November 27, 2019 .
  18. ↑ Federal Office for Radiation Protection (BfS), German Childhood Cancer Register, Mainz: Epidemiological study on childhood cancer in the vicinity of nuclear power plants (KiKK study) , accessed on August 2, 2013
  19. ↑ Publication of the epidemiological study on childhood cancer in the vicinity of nuclear power plants. Archived from the original on March 19, 2011 ; Retrieved March 19, 2011 .
  20. ↑ NDR, the atomic lie on youtube
  21. ↑ a b Study: As solid as a rock. Umwelt-NEWS.de, January 10, 2008, archived from the original on March 22, 2011 ; Retrieved March 22, 2011 .
  22. ^ Society of Epidemiological Cancer Registers in Germany. Retrieved November 27, 2019 .

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