Discovering Dengue Drugs - Together
| Discovering Dengue Drugs - Together | |
|---|---|
| Area: | Disease control |
| Target: | Testing of possible drugs for dengue fever , hepatitis C , West Nile virus , yellow fever and other viruses of the Flaviviridae family |
| Operator: | University of Texas Medical Branch, Infrastructure sponsored by IBM |
| Country: | United States |
| Platform: | BOINC |
| Website: | http://www.utmb.edu/discoveringdenguedrugs-together/ |
| Project status | |
| Status: | active |
| Start: | February 17, 2010 |
| The End: | 22th of March 2013 |
Discovering Dengue Drugs - Together is a project of the World Community Grid for distributed computing . The aim of the project is to find a drug that stops the replication of the viruses of the Flaviviridae family - including diseases such as dengue fever , hepatitis C , West Nile virus and yellow fever . With the donated computing time, a structure-based drug search is carried out. The most promising candidates are then efficiently tested in the laboratory.
In the first phase of the Discovering Dengue Drugs - Together project (August 21, 2007 to August 26, 2009), several thousands of drug-like molecules were found. In the second phase of the project, these hits will be examined more closely - it is assumed that 90–95% of the molecules found in the first phase are false positive and can be eliminated by the second phase.
To participate, after registering on the World Community Grid website, a small program (the so-called "Grid Client") must be installed, which is available for Windows , Linux and Mac as part of the BOINC software. This program then gets a task package from the website.
The results of the calculations are made available to research in the public domain.