EMPACT

The EMPACT syndrome , an acronym for E rythema exsudativum M ultiforme by P henytoin A nd (and) C raniale beams T herapie , is an acute inflammatory reaction of the skin to irradiation of the head and simultaneous delivery of the drug phenytoin, opposite seizures used becomes.

The name was first proposed in 2004 by I. Ahmed and co-workers for the occurrence of erythema multiforme during radiation therapy of the brain skull while taking phenytoin.

The phenomenon has also been observed with phenobarbital .

The DRESS syndrome must be distinguished from a differential diagnosis .

literature

A. Vilas-Sueiro, I. Vázquez-Osorio, JM Suárez-Peñaranda, D. Sánchez-Aguilar: Erythema Multiforme Associated With Phenytoin and Cranial Radiation Therapy (EMPACT syndrome) in a Patient With Lung Cancer. In: Actas dermo-sifiliograficas. Vol. 107, No. 2, March 2016, pp. 169–170, doi: 10.1016 / j.ad.2015.06.010 , PMID 26593687 .

AJ Bishop, M. Chang, ME Lacouture, CA Barker: EMPACT syndrome: limited evidence despite a high-risk cohort. In: Journal of neuro-oncology. Vol. 119, No. 1, August 2014, pp. 129-134, doi: 10.1007 / s11060-014-1457-7 , PMID 24792490 , PMC 4712043 (free full text).

Individual evidence

↑ I. Ahmed, J. Reichenberg, A. Lucas, JM Shehan: Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature. In: International journal of dermatology. Vol. 43, No. 1, January 2004, pp. 67-73, PMID 14693027 (review).
↑ K. Aydoğan, S. Vatansever, SB Adim, H. Saricaoglu: Empact syndrome: a case report and review of the literature. In: International journal of dermatology. Vol. 49, No. 8, August 2010, pp. 945-949, doi: 10.1111 / j.1365-4632.2009.04338.x , PMID 21128922 (review).
↑ G. Fabbrocini, L. Panariello, M. Pensabene, R. Lauria, E. Matano, D. Martellotta, D. Bianca, S. De Placido, F. Ayala: EMPACT syndrome associated with phenobarbital. In: Dermatitis: contact, atopic, occupational, drug. Vol. 24, No. 1, 2013 Jan-Feb, pp. 37-39, doi: 10.1097 / DER.0b013e31827ede32 , PMID 23340399 .

[1] I. Ahmed, J. Reichenberg, A. Lucas, JM Shehan: Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature. In: International journal of dermatology. Vol. 43, No. 1, January 2004, pp. 67-73, PMID 14693027 (review).

[2] K. Aydoğan, S. Vatansever, SB Adim, H. Saricaoglu: Empact syndrome: a case report and review of the literature. In: International journal of dermatology. Vol. 49, No. 8, August 2010, pp. 945-949, doi: 10.1111 / j.1365-4632.2009.04338.x , PMID 21128922 (review).

[3] G. Fabbrocini, L. Panariello, M. Pensabene, R. Lauria, E. Matano, D. Martellotta, D. Bianca, S. De Placido, F. Ayala: EMPACT syndrome associated with phenobarbital. In: Dermatitis: contact, atopic, occupational, drug. Vol. 24, No. 1, 2013 Jan-Feb, pp. 37-39, doi: 10.1097 / DER.0b013e31827ede32 , PMID 23340399 .