DRESS syndrome

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Classification according to ICD-10
T88.7 Unspecified undesirable side effect of a drug or drug
T78.4 Other undesirable side effects, not elsewhere classified
ICD-10 online (WHO version 2019)

The DRESS syndrome , acronym for D rug R ash with E osinophilia and S ystemic S ymptoms, is a drug eruption with eosinophilia and systemic manifestations . It is a rare drug reaction with fever , skin rash, increase in liver values ​​with varying degrees of severity up to fatality . Carbamazepine and phenytoin used to be common triggers .

Synonyms are: drug reaction syndrome with eosinophilia and systemic symptoms; Carbamazepine phenytoin hypersensitivity syndrome; DIDMOH; DIHS; Hypersensitivity syndrome; HSS; english drug hypersensitivity syndrome; drug induced delayed multiorgan hypersensitivity syndrome; drug-induced hypersensitivity syndrome; drug reaction with eosinophilia and systemic symptoms

The first description comes from 1959 by the US dermatologists Sidney L. Saltzstein and Lauren V. Ackermann.

The term "DRESS" was coined in 1996 by the French dermatologist H. Bocquet and colleagues.

Spread and cause

The frequency is not known.

The most common triggers are anticonvulsants , abacavir , allopurinol , dapsone , minocycline , modafinil , nevirapine , olanzapine , strontium ranelate , sulfonamides , vancomycin , ziprasidone . A reactivation of human herpes virus 6 and genetic disposition are discussed .

Clinical manifestations

Clinical criteria are:

Mortality is 10%

Differential diagnosis

The following are to be distinguished:

therapy

In addition to discontinuing the trigger, steroids and antihistamines are available for treatment .

literature

  • J. James, YM Sammour, AR Virata, TA Nordin, I. Dumic: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Secondary to Furosemide: Case Report and Review of Literature. In: The American journal of case reports. Vol. 19, February 2018, pp. 163–170, PMID 29440628 , PMC 5819310 (free full text).
  • UD Kombila, W. Ka, FB Mbaye, NF Diouf, L. Fall, P. Ouedraogo, AN Koutonin, Y. Dia Kane, N. Oumar Toure Badiane: DRESS syndrome au pyrazinamide: complication rare et grave du traitement antituberculeux. In: Revue des maladies respiratoires. Vol. 35, No. 1, January 2018, pp. 69-73, doi: 10.1016 / j.rmr.2017.02.007 , PMID 29429561 .
  • M. Pirklbauer, J. Gruber: DRESS syndrome after sulfasalazine therapy. In: Journal of Rheumatology. Vol. 73, No. 2, March 2014, pp. 180-183, doi: 10.1007 / s00393-013-1308-5 , PMID 24337150 .
  • S. Ständer, D. Metze, T. Luger, T. Schwarz: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An overview. In: The dermatologist ; Journal of Dermatology, Venereology, and Allied Fields. Vol. 64, No. 8, August 2013, pp. 611-622, doi: 10.1007 / s00105-013-2615-0 , PMID 23954978 (review).

Individual evidence

  1. ↑ a b Encyclopedia Dermatology
  2. ↑ a b c Drug eruption with eosinophilia and systemic manifestations. In: Orphanet (Rare Disease Database).
  3. ↑ SL Saltzstein, LV Ackermann: Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically pathologically malignant lymphomas. In: Cancer. Vol. 12, No. 1, 1959 Jan-Feb, pp. 164-182, PMID 13618867 .
  4. ↑ H. Bocquet, M. Bagot, JC Roujeau: Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS). In: Seminars in cutaneous medicine and surgery. Vol. 15, No. 4, December 1996, pp. 250-257, PMID 9069593 (review).
  5. ↑ a b c Entry on DRESS syndrome in Flexikon , a Wiki of the DocCheck company
  6. ↑ H. Anil, K. Harmanci, RT Tekin, A. Kocak: Presence of a single nucleotide polymorphism (RS3758581) in a boy with DRESS syndrome. In: Central-European Journal of Immunology. Vol. 42, No. 4, 2017, pp. 409-411, doi: 10.5114 / ceji.2017.72821 , PMID 29472822 , PMC 5820983 (free full text).
  7. ↑ SA Walsh, D. Creamer: Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking. In: Clinical and experimental dermatology. Vol. 36, No. 1, January 2011, pp. 6-11, doi: 10.1111 / j.1365-2230.2010.03967.x , PMID 21143513 (review).

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