Effectomer
An effectomer is a molecule or a part of a molecule which, in larger molecules or molecular complexes, is responsible for a biological effect in a target cell and is introduced into the target cell with the help of a haptomer unit. The terms haptomer and effectomer are used in particular for lectins and other, mostly toxic proteins, in order to distinguish the cell-binding from the toxic part.
| Protein / protein complex | Haptomer | Effectomer | Specificity of the effectomer |
|---|---|---|---|
| Abrin | B subunit | A subunit | Inhibition of protein synthesis |
| Cholera toxin | B subunits | A subunit | Inhibition of signal transduction via G proteins |
| Diphtheria toxin | B subunit | A subunit | Inhibition of protein synthesis |
| Ricin | B subunit | A subunit | Inhibition of protein synthesis |
| Shiga toxin | B subunits | A subunit | Inhibition of protein synthesis |
literature
- Pei-Show Juo: Concise Dictionary of Biomedicine and Molecular Biology , 2nd edition, CRC Press, 2010, ISBN 1420041304 .