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Epi-, peri- and endoneurium on a nerve

The endoneurium (also epilemma ) is the fine layer of connective tissue around the myelin sheath of every myelinated nerve fiber . The associated cells are called endoneural cells . The endoneuria with their accompanying nerve fibers are grouped into so-called nerve fiber bundles, each bundle in turn having a protective covering called the perineurium . In sufficiently large nerves, many bundles are again combined in a larger group, which are then enveloped by the so-called epineurium .

The endoneurium contains the endoneural fluid, which shows traces of proteins . In the peripheral nervous system , the endoneural fluid theoretically corresponds to the cerebrospinal fluid of the central nervous system . In the event of damage in the peripheral nervous system, increased amounts of the endoneural fluid are released into the surrounding tissue, which can be detected during a neurographic magnetic resonance tomography and thus help in localizing damage in the peripheral nervous system.

The endoneurium runs along the nerve fiber, but is interrupted by septa, which come from the innermost layer of the perineurium. It contains fine bundles of fibrous connective tissue , mainly collagen , which are embedded in a matrix of the ground substance. This structure serves as a support for capillaries, which are arranged in it in extensive meshes.

See also

Individual evidence

  1. Elaine N. Marieb, Katja Hoehn: Human Anatomy & Physiology. 7th edition. Pearson, 2007, ISBN 978-0-8053-5909-1 , pp. 498-499.
  2. JP Fraher: The transitional zone and CNS regeneration. In: Journal of Anatomy. 196 No. 1. 2000, pp. 137-158, ISSN  0021-8782 PMID 10697296 .