Eudismic relationship

The eudismic ratio is a parameter derived from medicinal chemistry , which indicates the stereoselectivity of a protein for a chiral ligand . The eudismic ratio is the quotient of the affinity or the activity of the more effective enantiomer ( eutomer ) and the affinity or activity of the less effective enantiomer ( distomer ).

${\displaystyle E={\frac {K_{a}({\text{Eutomer}})}{K_{a}({\text{Distomer}})}}}$

The decadic logarithm of the eudismic ratio is also known as the eudismic index . A possible correlation between the affinity of a ligand and its eudismic ratio is described in Pfeiffer's rule .

Individual evidence

1. ^ Wermuth CG, Ganellin CR, Lindber P, Mitscher LA (1998). GLOSSARY OF TERMS USED IN MEDICINAL CHEMISTRY (IUPAC Recommendations 1998). In: Pure Appl. Chem. 70: 1129-1143.
2. ↑ Carsten Schmuck, Bernd Engels, Tanja Schirmeister, Reinhold Fink: Chemistry for Medicine , Pearson Studies, p. 404, ISBN 978-3-8273-7286-4 .
3. ^ Pfeiffer CC (1956). Optical isomerism and pharmacological action, a generalization. In: Science 124: 29-31. PMID 13337345 .