Fibrocyte

from Wikipedia, the free encyclopedia

Fibrocytes are fixed (immobile) cells of the connective tissue with a long oval nucleus and long processes. These connect the cells with each other and form a three-dimensional structure, which stabilizes the otherwise loose connective tissue. The fibrocytes themselves, however, rest: the formation of the intercellular substance is carried out by the fibroblasts as their mobile precursor. However, if necessary, i.e. to form scarring , the fibrocytes can divide and form new fibroblasts.

literature

  • A. Bellini, S. Mattoli: The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. In: Laboratory Investigation . 2007, Volume 87, No. 9, pp. 858-870. PMID 17607298 .
  • M. Ogawa, AC LaRue, CJ Drake: Hematopoietic origin of fibroblasts / myofibroblasts: Its pathophysiologic implications. In: Blood , 2006, Volume 108, No. 9, pp. 2893-2896. PMID 16840726 .
  • S. Dunsmore, SD Shapiro: The bone marrow leaves its scar: new concepts in pulmonary fibrosis. In: The Journal of clinical investigation. (J Clin Invest) 2004, Vol. 113, No. 2, pp. 180-182, PMID 14722608 .