Ficoline

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Ficolines are a group of proteins of the complement system that bind N-acetylglucosamine as lectins .

properties

Depending on the protein domain , ficolines have structural homologies to collagen and fibronectin . Among the fibronectin-related protein domains, those of the ficoline have the highest mutation rate. Like the related collectins , e.g. B. Mannan- binding lectin (MBL), binds ficolin as a pattern recognition receptor to carbohydrates and then activates the lectin pathway of the complement system. Ficoline form multimers from twelve subunits (dodecamers) with a mass of 400 kilodaltons .

Three ficolines have been described in humans, FCN1 (synonym M-ficolin ), FCN2 (synonym L-ficolin ) and FCN3 (synonym H-ficolin ).

Individual evidence

  1. ↑ M. Matsushita: Ficolins: complement-activating lectins involved in innate immunity. In: Journal of Innate Immunity. Volume 2, number 1, 2010, pp. 24-32, doi : 10.1159 / 000228160 . PMID 20375620 .
  2. ↑ RF Doolittle, K. McNamara, K. Lin: Correlating structure and function during the evolution of fibrinogen-related domains. In: Protein Science: a publication of the Protein Society. Volume 21, Number 12, December 2012, pp. 1808-1823, doi : 10.1002 / pro.2177 . PMID 23076991 . PMC 3575912 (free full text).
  3. ↑ M. Cedzynski, AS Swierzko, DC Kilpatrick: Factors of the lectin pathway of complement activation and their clinical associations in neonates. In: Journal of Biomedicine & Biotechnology. Band 2012, 2012, pp 363246, doi : 10.1155 / 2012/363246 . PMID 22619494 . PMC 3348535 (free full text).
  4. ↑ Kilpatrick DC, Chalmers JD: Human L-ficolin (ficolin-2) and its clinical significance. In: Journal of Biomedicine & Biotechnology. Volume 2012, 2012, p. 138797, doi : 10.1155 / 2012/138797 . PMID 22500076 . PMC 3303570 (free full text).
  5. ↑ J. Lu, PN Tay, OL Kon, KB Reid: Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9. In: Biochemical Journal . Volume 313 (Pt 2), January 1996, pp. 473-478, PMID 8573080 . PMC 1216931 (free full text).
  6. ↑ Y. Endo, Y. Sato, M. Matsushita, T. Fujita: Cloning and characterization of the human lectin P35 gene and its related gene. In: Genomics. Volume 36, Number 3, September 1996, pp. 515-521, doi : 10.1006 / geno.1996.0497 . PMID 8884275 .
  7. ↑ R. Sugimoto, Y. Yae, M. Akaiwa, S. Kitajima, Y. Shibata, H. Sato, J. Hirata, K. Okochi, K. Izuhara, N. Hamasaki: Cloning and characterization of the Hakata antigen, a member of the ficolin / opsonin p35 lectin family. In: The Journal of Biological Chemistry . Volume 273, Number 33, August 1998, pp. 20721-20727, PMID 9694814 .