Fucoidan

Fucoidan is a natural compound found in various types of brown algae (Phaeophyceae) and in some marine animals such as marine snails , sea cucumbers and sea urchins and has attracted attention for its anti-cancer properties. Fucoidan is a sulfated polysaccharide , which contains the sugar fucose . As a mucilage, it is part of the cell wall of algae. Algae are an exceptionally diverse group of organisms. With regard to biomass, brown algae are the dominant organisms in many coastal regions; they have evolved independently and have many new features. Red and green algae , on the other hand, do not contain any fucoidan in their cell walls.

In East Asia, brown algae have been used in local cuisine and as medicine for centuries. Epidemiological studies have reported that the incidence of chronic diseases such as heart disease, diabetes and cancer is lower in China and Japan than in western countries, possibly due to different living and eating habits. This has led to renewed interest in the properties and ingredients of brown algae. In the past 50 years, more than 3000 ingredients derived from algae have been discovered. Laboratory studies suggest that fucoidan has neuroprotective and immunomodulatory effects. No human studies have been conducted to determine whether the same anti-cancer effects can occur. A human study suggests that fucoidan may help enable longer cycles of chemotherapy. However, more studies are needed to confirm its safety and effectiveness.

Individual evidence

↑ David J. Newman, Gordon M. Cragg, Kenneth M. Snader: Natural products as sources of new drugs over the period 1981-2002 . In: Journal of Natural Products . tape 66 , no. 7 , 2003, ISSN 0163-3864 , p. 1022-1037 , doi : 10.1021 / np030096l , PMID 12880330 .
^ J. Mark Cock, Akira F. Peters, Susana M. Coelho: Brown algae . In: Current biology: CB . tape 21 , no. 15 , August 9, 2011, ISSN 1879-0445 , p. R573-575 , doi : 10.1016 / j.cub.2011.05.006 , PMID 21820616 .
↑ Ludmylla Cunha, Ana Grenha: Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications . In: Marine Drugs . tape 14 , no. 3 , February 25, 2016, ISSN 1660-3397 , doi : 10.3390 / md14030042 , PMID 26927134 , PMC 4820297 (free full text).
↑ Kalu Kapuge Asanka Sanjeewa, Eun-A. Kim, Kwang-Tae Son, You-Jin Jeon: Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds: A review . In: Journal of Photochemistry and Photobiology. B, Biology . tape 162 , 2016, ISSN 1873-2682 , pp. 100-105 , doi : 10.1016 / j.jphotobiol.2016.06.027 , PMID 27362368 .
^ Lindsey A. Torre, Freddie Bray, Rebecca L. Siegel, Jacques Ferlay, Joannie Lortet-Tieulent: Global cancer statistics, 2012 . In: CA: a cancer journal for clinicians . tape 65 , no. 2 , 2015, ISSN 1542-4863 , p. 87-108 , doi : 10.3322 / caac.21262 , PMID 25651787 .
↑ Miguel C. Leal, Murray HG Munro, John W. Blunt, João Puga, Bruno Jesus: Biogeography and biodiscovery hotspots of macroalgal marine natural products . In: Natural Product Reports . tape 30 , no. 11 , October 11, 2013, ISSN 1460-4752 , p. 1380-1390 , doi : 10.1039 / c3np70057g , PMID 23982267 .
↑ Qi Ying Lean, Rajaraman D. Eri, J. Helen Fitton, Rahul P. Patel, Nuri Gueven: Fucoidan Extracts Ameliorate Acute Colitis . In: PloS One . tape 10 , no. 6 , 2015, ISSN 1932-6203 , p. e0128453 , doi : 10.1371 / journal.pone.0128453 , PMID 26083103 , PMC 4471193 (free full text).
↑ Diana M. Hernández-Corona, Esperanza Martínez-Abundis, Manuel González-Ortiz: Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults . In: Journal of Medicinal Food . tape 17 , no. 7 , 2014, ISSN 1557-7600 , p. 830-832 , doi : 10.1089 / jmf.2013.0053 , PMID 24611906 .
↑ Masahide Ikeguchi, Manabu Yamamoto, Yosuke Arai, Yoshihiko Maeta, Keigo Ashida: Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer . In: Oncology Letters . tape 2 , no. 2 , 2011, ISSN 1792-1074 , p. 319–322 , doi : 10.3892 / ol.2011.254 , PMID 22866084 , PMC 3410608 (free full text).
↑ Hidenori Takahashi, Mitsuhiko Kawaguchi, Kunihiro Kitamura, Seiji Narumiya, Munenori Kawamura: An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients . In: Integrative Cancer Therapies . tape 17 , no. 2 , 2018, ISSN 1552-695X , p. 282-291 , doi : 10.1177 / 1534735417692097 , PMID 28627320 , PMC 6041928 (free full text).

[1] David J. Newman, Gordon M. Cragg, Kenneth M. Snader: Natural products as sources of new drugs over the period 1981-2002 . In: Journal of Natural Products . tape 66 , no. 7 , 2003, ISSN 0163-3864 , p. 1022-1037 , doi : 10.1021 / np030096l , PMID 12880330 .

[2] J. Mark Cock, Akira F. Peters, Susana M. Coelho: Brown algae . In: Current biology: CB . tape 21 , no. 15 , August 9, 2011, ISSN 1879-0445 , p. R573-575 , doi : 10.1016 / j.cub.2011.05.006 , PMID 21820616 .

[3] Ludmylla Cunha, Ana Grenha: Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications . In: Marine Drugs . tape 14 , no. 3 , February 25, 2016, ISSN 1660-3397 , doi : 10.3390 / md14030042 , PMID 26927134 , PMC 4820297 (free full text).

[4] Kalu Kapuge Asanka Sanjeewa, Eun-A. Kim, Kwang-Tae Son, You-Jin Jeon: Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds: A review . In: Journal of Photochemistry and Photobiology. B, Biology . tape 162 , 2016, ISSN 1873-2682 , pp. 100-105 , doi : 10.1016 / j.jphotobiol.2016.06.027 , PMID 27362368 .

[5] Lindsey A. Torre, Freddie Bray, Rebecca L. Siegel, Jacques Ferlay, Joannie Lortet-Tieulent: Global cancer statistics, 2012 . In: CA: a cancer journal for clinicians . tape 65 , no. 2 , 2015, ISSN 1542-4863 , p. 87-108 , doi : 10.3322 / caac.21262 , PMID 25651787 .

[6] Miguel C. Leal, Murray HG Munro, John W. Blunt, João Puga, Bruno Jesus: Biogeography and biodiscovery hotspots of macroalgal marine natural products . In: Natural Product Reports . tape 30 , no. 11 , October 11, 2013, ISSN 1460-4752 , p. 1380-1390 , doi : 10.1039 / c3np70057g , PMID 23982267 .

[7] Qi Ying Lean, Rajaraman D. Eri, J. Helen Fitton, Rahul P. Patel, Nuri Gueven: Fucoidan Extracts Ameliorate Acute Colitis . In: PloS One . tape 10 , no. 6 , 2015, ISSN 1932-6203 , p. e0128453 , doi : 10.1371 / journal.pone.0128453 , PMID 26083103 , PMC 4471193 (free full text).

[8] Diana M. Hernández-Corona, Esperanza Martínez-Abundis, Manuel González-Ortiz: Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults . In: Journal of Medicinal Food . tape 17 , no. 7 , 2014, ISSN 1557-7600 , p. 830-832 , doi : 10.1089 / jmf.2013.0053 , PMID 24611906 .

[9] Masahide Ikeguchi, Manabu Yamamoto, Yosuke Arai, Yoshihiko Maeta, Keigo Ashida: Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer . In: Oncology Letters . tape 2 , no. 2 , 2011, ISSN 1792-1074 , p. 319–322 , doi : 10.3892 / ol.2011.254 , PMID 22866084 , PMC 3410608 (free full text).

[10] Hidenori Takahashi, Mitsuhiko Kawaguchi, Kunihiro Kitamura, Seiji Narumiya, Munenori Kawamura: An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients . In: Integrative Cancer Therapies . tape 17 , no. 2 , 2018, ISSN 1552-695X , p. 282-291 , doi : 10.1177 / 1534735417692097 , PMID 28627320 , PMC 6041928 (free full text).