Fucosylation

The fucosylation is a post-translational modification , in which a fucose to group proteins is appended.

properties

Fucosylation is a form of glycosylation of proteins. Fucosylation is catalyzed by fucosyltransferases . Altered fucosylation is a biomarker for cancer . Defects in the genes of fucosylation lead to LAD syndrome type II, in which selectins can no longer bind to an altered P-selectin glycoprotein 1 (PSGL-1) and thus leukocytes have impaired cell adhesion (no rolling of leukocytes along the vessel wall) and the Affected people have increased bacterial infections.

Individual evidence

↑ MN Christiansen, J. Chik, L. Lee, M. Anugraham, JL Abrahams, NH Packer: Cell surface protein glycosylation in cancer. In: Proteomics. Volume 14, number 4-5, March 2014, pp. 525-546, doi : 10.1002 / pmic.201300387 , PMID 24339177 .
^ ES Harris, AS Weyrich, GA Zimmerman: Lessons from rare maladies: leukocyte adhesion deficiency syndromes. In: Current Opinion in Hematology . Volume 20, number 1, January 2013, pp. 16-25, doi : 10.1097 / MOH.0b013e32835a0091 , PMID 23207660 , PMC 3564641 (free full text).
^ S. Schmidt, M. Moser, M. Sperandio: The molecular basis of leukocyte recruitment and its deficiencies. In: Molecular immunology. Volume 55, number 1, August 2013, pp. 49-58, doi : 10.1016 / j.molimm.2012.11.006 , PMID 23253941 .

[1] MN Christiansen, J. Chik, L. Lee, M. Anugraham, JL Abrahams, NH Packer: Cell surface protein glycosylation in cancer. In: Proteomics. Volume 14, number 4-5, March 2014, pp. 525-546, doi : 10.1002 / pmic.201300387 , PMID 24339177 .

[2] ES Harris, AS Weyrich, GA Zimmerman: Lessons from rare maladies: leukocyte adhesion deficiency syndromes. In: Current Opinion in Hematology . Volume 20, number 1, January 2013, pp. 16-25, doi : 10.1097 / MOH.0b013e32835a0091 , PMID 23207660 , PMC 3564641 (free full text).

[3] S. Schmidt, M. Moser, M. Sperandio: The molecular basis of leukocyte recruitment and its deficiencies. In: Molecular immunology. Volume 55, number 1, August 2013, pp. 49-58, doi : 10.1016 / j.molimm.2012.11.006 , PMID 23253941 .