Feathered glia of Fañanas

The pinnate glia of Fañanas (also Fañanas cells) are satellite glial cells that can be found in the cortex (Stratum purkinjense, Stratum molecularulare) of the cerebellum .

The Fañanas cells can only be visualized histologically with a special gold sublimate method .

histology

The cells are scattered in all levels of the molecular stratum, but clustered in the lower third. In some cases the cell bodies are already in the stratum purkinjese. Their cytoplasmic extensions do not contain glial filaments or acidic glial fiber protein . They stand opposite the extensions of the epithelial Golgi cells, the Bergmann glia , which, as Purkinje cell processes, form the second important glial cell population in the cerebellar cortex. Some authors attribute a close relationship to the Fañanas cells to the epithelial Golgi cells, others see them as a subtype.

The Fañanas cells are divided according to their morphology into

mono-feathered
bifurcated
multiple pinnate

Fañanas cells are usually not involved in the glial border membrane ( Membrana limitans gliae ), in contrast to the Bergmann glia.

history

The feathered cells of Fañanas were discovered in 1916 by Jorge Ramón y Cajal Fañanás, a son of Ramón y Cajal . Today they have largely been forgotten because of their unexplained clinical facts. A clear function could not be assigned to these cells either.

clinic

The Fañanas cells are rarely part of clinical studies and laboratory tests.

In connection with Creuztfeldt-Jakob disease , however, this glial cell type was examined for changes in addition to Bergmann's glia, microglia and astrocytes . In this context, expression of vimentin was found in Fañanas cells, Bergmann glia and the microglia , while only a small amount of reactive astrocytes were vimentin-positive. However, this finding only supports the thesis that the astroglia in particular play a central role in CJD, while the influence of Fañanas-Glia does not seem to be significant.

Individual evidence

↑ M. Lakomy: Glioarchitectonics of the cerebellar cortex and medulla of cows during postnatal development . In: Pol Arch Weter . 1980, p. 433-443 .
↑ ^a ^b Karl Uwe Petersen: On the fine structure of the neuroglial cells in the cerebellar cortex of mammals . In: Journal for Cell Research and Microscopic Anatomy . December 1969, p. 613-633 .
^ ^A ^b S. T. Bok, R. Greving, A Jakob, G. Mingazzini, Ph. Stöhr: Nervous system: first part of nerve tissue, the peripheral nervous system, the central nervous system . Springer, Berlin / Heidelberg 1928, OCLC 913707316 .
↑ ^a ^b Jan Jansen, Alf Brodal: Nervous system - eighth part - the cerebellum . Springer-Verlag, Berlin / Heidelberg 1958, ISBN 978-3-662-21750-4 , p. 147 .
↑ ^a ^b Andreas Plaitakis: Cerebellar Degeneration: Clinical Neurobiology . In: Springer Science & Business Media . May 31, 1992, p. 220 .
↑ M. Lafarga, MT Berciano, MA Andres, J. Berciano: Reactive astroglia-neuron relationships in the human cerebellar cortex: a quantitative, morphological and immunocytochemical study in Creutzfeldt-Jakob disease . In: Int J Dev Neurosci. April 1993, p. 199-213 .

[1] M. Lakomy: Glioarchitectonics of the cerebellar cortex and medulla of cows during postnatal development . In: Pol Arch Weter . 1980, p. 433-443 .

[:1-2] Karl Uwe Petersen: On the fine structure of the neuroglial cells in the cerebellar cortex of mammals . In: Journal for Cell Research and Microscopic Anatomy . December 1969, p. 613-633 .

[:0-3] A ^b S. T. Bok, R. Greving, A Jakob, G. Mingazzini, Ph. Stöhr: Nervous system: first part of nerve tissue, the peripheral nervous system, the central nervous system . Springer, Berlin / Heidelberg 1928, OCLC 913707316 .

[:2-4] Jan Jansen, Alf Brodal: Nervous system - eighth part - the cerebellum . Springer-Verlag, Berlin / Heidelberg 1958, ISBN 978-3-662-21750-4 , p. 147 .

[:3-5] Andreas Plaitakis: Cerebellar Degeneration: Clinical Neurobiology . In: Springer Science & Business Media . May 31, 1992, p. 220 .

[6] M. Lafarga, MT Berciano, MA Andres, J. Berciano: Reactive astroglia-neuron relationships in the human cerebellar cortex: a quantitative, morphological and immunocytochemical study in Creutzfeldt-Jakob disease . In: Int J Dev Neurosci. April 1993, p. 199-213 .