Ghon complex
The term Ghon complex (Syn .: Ghon focus, primary complex) describes radiologically detectable signs of primary tuberculosis, an infection with Mycobacterium tuberculosis . The complex consists of the pneumonic primary focus and the affected hilar lymph nodes (lymphadenopathy). They were named after the Austrian anatomist and pathologist Anton Ghon .
The mycobacterium tuberculosis is one of the acid-fast rods and, due to its high lipid and wax content, is largely insusceptible to the lysozymes of the macrophages. This leads to the fact that a chronic inflammation develops in the form of tuberculosis granulomas, which v. a. may lie subpleural in the lower portions of the upper lobe as well as in the upper portion of the lower lobe of the lung.
The macrophages, which are loaded with mycobacteria, are brought via the lymph to locally draining lymph nodes, where a granulomatous reaction also takes place. Under certain circumstances, due to calcifications, they can turn into a so-called Ghon complex, which can be seen radiologically in the lung overview image. If this Ghon complex continues to heal and is remodeled fibrotic , one speaks of a tendril complex.
Individual evidence
- ↑ Edward F. Goljan: Rapid Review Pathology , 4th Edition, ISBN 978-0-323-08787-2 , page 392
- ^ Tinsley R. Harrison: Harrisons internal medicine , 18th edition, Ch. 165, ISBN 3-89028-852-9 , p. 1442