Glucose autoregulation

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The glucose autoregulation refers to a from insulin -independent regulation of cellular uptake of glucose , the exact mechanism is not yet known.

Components of the control loop

An important structure of the autoregulation of the glucose level is the blood sugar dependent net glucose production or utilization of the liver . When the blood sugar level is high, net glucose consumption predominates; when the blood sugar level is low, glucose production takes over.

The opposite effect exists in the central nervous system : Here glucose uptake is stimulated when the blood sugar level is low, which protects the nerve cells from destruction. However, this mechanism is slow. In particular, it does not protect against the harmful effects of sudden and severe hypoglycemia .

Prolonged presence of low blood sugar levels increases the uptake of glucose in the skeletal muscle , while pre-existing high blood sugar levels have the opposite effect.

Individual evidence

  1. ↑ Bucolo RJ, Bergman RN, Marsh DJ, Yates FE. Dynamics of glucose autoregulation in the isolated, blood-perfused canine liver. Am J Physiol. 1974 Jul; 227 (1): 209-17. PMID 4843372 .
  2. ↑ Davidson MB. Autoregulation by glucose of hepatic glucose balance: permissive effect of insulin. Metabolism. 1981 Mar; 30 (3): 279-84. PMID 7010073 .
  3. ^ Moore MC, Connolly CC, Cherrington AD. Autoregulation of hepatic glucose production. Eur J Endocrinol. 1998 Mar; 138 (3): 240-8. Review. PMID 9539293 .
  4. ↑ Camacho RC, Lacy DB, James FD, Coker RH, Wasserman DH. Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose. Am J Physiol Endocrinol Metab. 2004 Aug; 287 (2): E269-74. Epub 2004 Mar 30. PMID 15053988 .