Gordon J. Freeman

Gordon J. Freeman is an immunologist and oncologist at the Dana-Farber Cancer Institute and Harvard Medical School .

Freeman deals with stimulating and inhibiting signals in the process of the immune response . He was instrumental in clarifying the importance of B7-1 , B7-2 and other members of the B7 gene family as well as CD28 and CTLA-4 in T-cell activation and PD-L1 / PD-1 (Programmed cell death protein 1) Contribute in inhibiting T cell activation. Blocking the PD-1 metabolic pathway represents an important new possibility in cancer therapy (see for example pembrolizumab ).

Freeman earned a bachelor's degree in biochemistry and molecular biology from Harvard University . In 1979 he obtained a Ph.D. and then worked as a postdoctoral fellow with Harvey Cantor and Lee Nadler at the Dana-Farber Cancer Institute (DFCI). As of 2016, he heads a working group at the DFCI and is Professor of Internal Medicine at Harvard Medical School .

In 2014 Freeman received the William B. Coley Award together with Tasuku Honjo , Lieping Chen and Arlene Sharpe .

Since 2016 Thomson Reuters Freeman (together with Honjo and Sharpe) has been one of the favorites for a Nobel Prize ( Thomson Reuters Citation Laureates ) due to the number of citations it has received . In 2017 Freeman was one of the winners of the Warren Alpert Foundation Prize .

Web links

• Gordon J. Freeman, PhD and profile at the Dana-Farber Cancer Institute (dana-farber.org)
• Gordon J. Freeman, PhD at Harvard Medical School (harvard.edu)

Individual evidence

1. ^ William B. Coley Award. In: cancerresearch.org. Retrieved October 2, 2016 . 
2. ↑ Matthew Tontonoz: CRI Names Winners of Top Scientific Prize. In: cancerresearch.org. September 3, 2014, accessed October 2, 2016 . 
3. ↑ Web of Science Predicts 2016 Nobel Prize Winners. (No longer available online.) In: ipscience.thomsonreuters.com. September 21, 2016, archived from the original on September 21, 2016 ; accessed on October 2, 2016 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.