HPU
HPU is the abbreviation for:
- Hemopyrrollactamuria , a form of the disease porphyrinuria
- Hawaii Pacific University in Honolulu and Kaneohe, Hawaii, USA
- Howard Payne University in Brownwood, Texas, USA
- High Point University in High Point, North Carolina, USA
- the material hydrolysis-resistant polyurethane, also called thermoplastic polyurethane, see Polyurethane
- Greater Poland Voivodeship , Poland (police license plate)