Hamburger shift

As chloride shift , named after Hartog Jakob hamburger , in which is physiology of the anion in the erythrocytes by means of a Cl ^- / HCO ₃ ^- - antiporter designated. The CO ₂ diffused in the body periphery from the tissue into the blood capillary and then into the erythrocytes reacts with H ₂ O, catalyzed by carbonic anhydrase , according to the following equation:

${\displaystyle \mathrm {CO_{2}+H_{2}O\rightleftharpoons H_{2}CO_{3}\rightleftharpoons {HCO{_{3}}^{-}}+H^{+}} }$

The HCO ₃ ^- leaves the erythrocytes via the hamburger shift, the now increased intracellular concentration of H ⁺ ions leads to a slight acidification of the erythrocytes and the pH value decreases. In conjunction with the increased CO ₂ concentration, there is a shift to the right of the oxygen binding curve and thus a decrease in the O ₂ affinity of hemoglobin (Bohr effect), the oxygen is more easily released to the tissue.

See also

• Haldane effect

Individual evidence

1. ↑ S. Silbernagl, A. Despopoulos: Pocket Atlas of Physiology . 5th edition. Thieme, Stuttgart 2001, ISBN 978-3-13-567707-1 , p. 124 .
2. ↑ JC Behrends et al .: Physiology (Dual Series) . 1st edition. Thieme, Stuttgart 2010, ISBN 978-3-13-138411-9 , p. 252-253 .