Hegar sign

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The Hegar sign is a probable sign of pregnancy named after the gynecologist Alfred Hegar . In the second and third months of pregnancy, the area of ​​the isthmus uteri , which lies between the body of the uterus ( corpus uteri ) and the cervix ( cervix uteri ), is softer and easier to compress when palpated . The cause is a change in the composition of the connective tissue during pregnancy due to the activation of proteases . This leads to an increased storage of water and a reorganization and relative reduction of the collagen fibrils .

literature

  • E. Sunday: Hegar's sign of pregnancy . In: Richard von Volkmann : Collection of clinical lectures . No. 58, Leipzig 1892.
  • A. Hegar: Diagnosis of the earliest gestation period . In: German Medical Weekly . Berlin 1895, 21 (35): 565-567.
  • N. Uldbjerg, U. Ulmsten: The physiology of cervical ripening and cervical dilatation and the effect of abortifacient drugs. In: Baillière's clinical obstetrics and gynecology. Volume 4, Number 2, June 1990, pp. 263-282, ISSN  0950-3552 . PMID 2225599 . (Review).
  • N. Uldbjerg, G. Ekman, A. Malmström, K. Olsson, U. Ulmsten: Ripening of the human uterine cervix related to changes in collagen, glycosaminoglycans, and collagenolytic activity. In: American Journal of Obstetrics and Gynecology . Volume 147, Number 6, November 1983, pp. 662-666, ISSN  0002-9378 . PMID 6638110 .