Heinrich Jasper (molecular biologist)

Heinrich Jasper , also Henri Jasper, (born February 1, 1974 ) is a German molecular biologist who deals with age research.

Life

Jasper studied at the University of Tübingen with a diploma in 1998 and received his doctorate in 2001 at the University of Heidelberg and at the European Molecular Biology Laboratory under Dirk Bohmann (Analysis of signaling and cell differentiation events in Drosophila development by genome-wide expression profiling), where he was responsible for regulation of developmental processes in Drosophila . He then went to the University of Rochester Medical Center, where he became Research Assistant Professor in 2003 and Assistant Professor in 2005. In 2012 he joined the Buck Institute for Research on Aging in Novato , California. There he also worked with the laboratories of Brian Kennedy and Pankaj Kapahi. He is also at the Leibniz Institute for Aging Research (FLI) in Jena .

Jasper examines the effects of aging, metabolism and stress on stem cells and, in particular, on their ability to renew damaged tissue. He uses Drosophila as a model system and examined stem cells in its intestines, in which tissue has to be renewed particularly frequently, and later also in the respiratory system of mice. Jasper found various signaling pathways that regulate the multiplication of stem cells.

He received the Ellison Medical Foundation's Senior Scholar in Aging Award and the Glenn / AFAR Breakthroughs in Gerontology Award. In 2016 he received a Humboldt Professorship .

Fonts (selection)

with Meng C. Wang, Dirk Bohlmann: JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila, Developmental Cell, Volume 5, 2003, pp. 811-816
with Benoit Biteau, Christine E. Hochmuth: JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut, Cell Stem Cell, Volume 3, 2008, pp. 442–455, PMID 18940735
with B. Biteau a. a .: Lifespan extension by preserving proliferative homeostasis in Drosophila, PLoS Genet, 6, 2010, e1001159, PMID 20976250
with Biteau, Hochmuth: Maintaining tissue homeostasis: dynamic control of somatic stem cell activity, Cell Stem Cell, Volume 9, 2011, pp. 402-411, PMID 22056138
with B. Biteau: EGF signaling regulates the proliferation of intestinal stem cells in Drosophila, Development, Volume 138, 2011, pp. 1045-1055, PMID 21307097
with Hansong Deng, Akos A Gerencser: Signal integration by Ca (2+) regulates intestinal stem-cell activity, Nature, Volume 528, 2015, pp. 212-217
with Samantha Haller: You Are What You Eat: Linking High-Fat Diet to Stem Cell Dysfunction and Tumorigenesis, Cell Stem Cell, Volume 18, 2016, pp. 564-566

Web links

personal data
SURNAME	Jasper, Heinrich
ALTERNATIVE NAMES	Jasper, Henri
BRIEF DESCRIPTION	German molecular biologist
DATE OF BIRTH	1st February 1974