High mobility group proteins
The High-Mobility Group or HMG is a protein structure motif and at the same time the name of a group of DNA-binding proteins that play a role in transcription , replication , recombination and DNA repair .
HMG-box proteins are found in a large number of eukaryotic organisms.
HMG proteins were originally isolated from mammalian cells and named after their electrophoretic mobility in polyacrylamide gels.
Classification
The High-Mobility Group proteins are divided into three families, each with a characteristic domain .
- HMGN - has a nucleosomal binding domain
- TCF Transcription Factors
- Lymphoid enhancer-binding factor 1
- T Cell Transcription Factor 1
Individual evidence
- ↑ Johns EB: The HMG chromosomal proteins . Academic Press, Boston 1982, ISBN 0-12-386050-4 .