High mobility group proteins

The High-Mobility Group or HMG is a protein structure motif and at the same time the name of a group of DNA-binding proteins that play a role in transcription , replication , recombination and DNA repair .

HMG-box proteins are found in a large number of eukaryotic organisms.

HMG proteins were originally isolated from mammalian cells and named after their electrophoretic mobility in polyacrylamide gels.

Classification

The High-Mobility Group proteins are divided into three families, each with a characteristic domain .

• HMGA - have three AT-hook domains
  • HMGA1
  • HMGA2

• HMGB - owns an HMG-box domain
  • HMGB1
  • HMGB2
  • HMGB3
  • HMGB4

• HMGN - has a nucleosomal binding domain
  • HMGN1 protein
  • HMGN2 protein
  • HMGN4 protein

• Sex-Determining Region Y Protein

• TCF Transcription Factors
  • Lymphoid enhancer-binding factor 1
  • T Cell Transcription Factor 1

Individual evidence

1. ↑ Johns EB: The HMG chromosomal proteins . Academic Press, Boston 1982, ISBN 0-12-386050-4 .