Huh-7

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In Huh7 (also Huh7 ) is a cell line derived from malignant liver cells (hepatocytes malignant) was obtained. According to the website huh7.com, it is "a well-differentiated, hepatocyte-derived carcinoma cell line obtained from a liver tumor in a 57-year-old Japanese male patient in 1982". It is widely used in hepatitis C and dengue virus research.

Huh7 cells have been used extensively in hepatitis C research. Until 2005 it was not possible to cultivate hepatitis C viruses in the laboratory. The introduction of the Huh7 cell line allowed the screening of drug candidates against cultured in the laboratory Hepatitis C virus and the development of new drugs against hepatitis C.

Individual evidence

  1. ^ Huh-7 Cell Line Origins and Characteristics . Retrieved March 29, 2020.
  2. ↑ a b Bruno Sainz, Veronica Tencate, Susan L Uprichard: Three-dimensional Huh7 cell culture system for the study of hepatitis C virus infection . In: Virology Journal . 6, 2009, p. 103. doi : 10.1186 / 1743-422X-6-103 . PMID 19604376 . PMC 2719612 (free full text).
  3. ↑ Mira AM Behnam, Christoph Nitsche, Veaceslav Boldescu, Christian D. Klein: The medicinal chemistry of dengue virus . In: Journal of Medicinal Chemistry . 59, No. 12, 2016, p. 5622. doi : 10.1021 / acs.jmedchem.5b01653 . PMID 26771861 .
  4. ^ R Bartenschlager, T Pietschmann: Efficient hepatitis C virus cell culture system: what a difference the host cell makes . In: Proceedings of the National Academy of Sciences of the United States of America . 102, No. 28, 2005, pp. 9739-9740. doi : 10.1073 / pnas.0504296102 . PMID 15998731 . PMC 1175013 (free full text).
  5. ↑ Volker Meier, Giuliano Ramadori: Hepatitis C virus virology and new treatment targets . In: Expert Review of Anti-infective Therapy . 7, No. 3, 2009, pp. 329-350. doi : 10.1586 / eri.09.12 . PMID 19344246 .

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