Dengue virus
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Dengue viruses (black dots in the middle). |
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The dengue virus is a virus , which in humans and other primates , a hemorrhagic fever , known as dengue fever can trigger. The virus is transmitted by mosquitoes of various genera (e.g. Aedes ). When an infected primate bites, the mosquito ingests the virus, which then multiplies in the mosquito and infects the salivary glands. It is passed on through the saliva with the next bite.
properties
The dengue virus belongs to the Flaviviridae family , whose members typically have a single-stranded RNA with positive polarity as the genome , which is surrounded by a spherical capsid . The RNA genome is complexed with the dimerized capsid protein C as a nucleocapsid . The capsid is from one of the host cell derived membrane wrapped, in which the structural proteins M and E are stored. Protein E in particular is prominent on the surface of the virus particle (virion) and therefore acts as an antigen .
The positive-stranded RNA is about 11,000 nucleotides long and includes only one open reading frame that codes for a polyprotein . Proteases cut this polyprotein into three structural (C, prM, E) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5); the list corresponds to the arrangement of the genes coding for the proteins on the genome.
Infections with the dengue virus can be used for training of infection-enhancing antibodies lead to a challenge in the development of dengue virus vaccines represent.
Reporting requirement
In Germany, direct or indirect evidence of the dengue virus must be reported by name in accordance with Section 7 of the Infection Protection Act , provided the evidence indicates an acute infection.
In Switzerland, positive laboratory analysis results for the dengue virus must be reported in accordance with the Epidemics Act (EpG) in conjunction with the Epidemics Ordinance and Appendix 3 of the EDI Ordinance on the reporting of observations of communicable diseases in humans .
Web links
- UTMB researchers have discovered a new antiviral mechanism for dengue therapeutics , on: EurekAlert! from July 13, 2020, Source: University of Texas Medical Branch at Galveston (News Release)
Individual evidence
- ↑ ICTV Master Species List 2018b.v2 . MSL # 34, March 2019
- ↑ a b c d ICTV: ICTV Taxonomy history: Yellow fever virus , EC 51, Berlin, Germany, July 2019; Email ratification March 2020 (MSL # 35)
- ^ Sampath A, Padmanabhan R: Molecular targets for flavivirus drug discovery . In: Antiviral Research . 81, No. 1, January 2009, pp. 6-15. doi : 10.1016 / j.antiviral.2008.08.004 . PMID 18796313 .
