Immunomagnetic separation

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The immunomagnetic separation ( IMS ) is a laboratory process by which cells can be removed effectively from body fluids or cell cultures. It can also be used to quantify the pathogenicity of blood, food, or feces. Paramagnetic beads coated with antibody bind specific cellular components on the host surface and thereby capture these cells. A magnet is then attached to the outside of the test vessel, which attracts the cells bound to the beads and thereby concentrates them.

An alternative separation method is affinity magnetic separation (AMS), which is more suitable for the isolation of prokaryotic cells.

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  • Engstrand, L. and Enroth, H .: Journal of Clinical microbiology , vol. 33, no. 8, August 1995, p. 2162-2165.
  • Coupling of immunomagnetic separation and ELISA for rapid detection of Salmonella in foods in the meat industry 7/1996, p. 749