Inulin clearance

The determination of the inulin clearance is a method for determining the glomerular filtration rate , which, however, is methodologically too complex for routine use. For this reason, the determination of the endogenous creatinine clearance is currently used in the laboratory , although this is subject to the interfering influences of the creatinine determination and is additionally prone to errors due to errors during the urine collection period.

For some time now, cystatin C has been available, a significantly more sensitive and specific parameter that allows a significantly better and more trouble-free assessment of kidney function, even in the creatinine-blind area .

Implementation of the procedure

At the beginning, blood is drawn from the patient. After that, the patient needs to drink 500 ml of water. Then 5 g of inulin are injected intravenously ( IV) over five minutes . Two more blood samples are taken 3 and 45 minutes after the injection is complete.

See also

• p-aminohippuric acid

Web links

• Encyclopedia Britannica: inulin clearance (English)
• K / DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. In: American Journal of Kidney Diseases . Volume 39, Number 2 Suppl 1, February 2002, pp. S1-266, PMID 11904577 .

Individual evidence

1. ↑ Determination of the glomerular filtration rate in children and adolescents: alternative methods for inulin clearance and the influence of laboratory test methods. (PDF; 1.9 MB) Retrieved May 10, 2010 . 

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !