Katrin Schröder (biologist)

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Katrin Schröder (* 1975 in Grevesmühlen ) is a German biologist and physiologist .

Life

Schröder attended schools in Klütz and Grevesmühlen. From 1994 to 1998 she studied biology at the University of Rostock , where she graduated from the Department of Animal Physiology in 1999. From 1999 to 2003 she worked as a research assistant in the medical department at the Institute of Biochemistry and received her doctorate in 2003 with the thesis “Molecular mechanisms of action of growth-regulating cytokines: The protein kinase R in interferon alpha signal transfer”.

After various positions as a postdoc, she completed her habilitation in 2011 in the subject of physiology with the thesis "NADPH oxidases in the cardiovascular system - differential functions of Nox2 and Nox4" . Schröder has been Professor of Vegetative Physiology at the Institute for Cardiovascular Physiology at the University Medical Center Frankfurt am Main since 2016 .

Act

Schröder's research focuses on the functions of NADPH oxidases . She demonstrated that the oxygen radicals produced by NADPH oxidases are not exclusively harmful, but can also act as messenger substances in the cell's signal transduction . In endothelial cells , i.e. the cells that represent the lining of the blood vessels, individual members of the NADPH oxidase family mediate very different effects. They contribute to the regeneration of damaged endothelial areas, prevent apoptosis and the proinflammatory activation of the endothelial cells and are involved in the formation of new blood vessels (angiogenesis).

Other works by Schröder deal with the differentiation of cells. She showed that a certain NADPH oxidase plays a key role in the differentiation of adipocytes (fat cells) and osteoclasts (bone-degrading cells) from the corresponding progenitor cells . Two patents have emerged from this and other work, which may lead to the development of new drugs, for example against osteoporosis (bone loss).

Awards (selection)

  • 2011: Du Bois Remond Prize of the German Physiological Society
  • 2013: Albert Fraenkel Prize of the German Cardiological Society
  • 2015: Dr. Paul and Cilli Weill Foundation for young scientists

Publications (selection)

  • C. Schürmann, F. Rezende, C. Kruse, Y. Yasar, O. Löwe, C. Fork, B. van de Sluis, R. Bremer, N. Weissmann, AM Shah, H. Jo, RP Brandes, K. Schröder: The NADPH oxidase Nox4 has anti-atherosclerotic functions. In: European heart journal. Volume 36, number 48, December 2015, pp. 3447-3456, doi : 10.1093 / eurheartj / ehv460 , PMID 26385958 , PMC 4751217 (free full text).
  • C. Goettsch, A. Babelova, O. Trummer, RG Erben, M. Rauner, S. Rammelt, N. Weissmann, V. Weinberger, S. Benkhoff, M. Kampschulte, B. Obermayer-Pietsch, LC Hofbauer, RP Brandes , K. Schröder: NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. In: The Journal of clinical investigation. Volume 123, number 11, November 2013, pp. 4731-4738, doi : 10.1172 / JCI67603 , PMID 24216508 , PMC 3809780 (free full text).
  • K. Schröder, M. Zhang, S. Benkhoff, A. Mieth, R. Pliquett, J. Kosowski, C. Kruse, P. Luedike, UR Michaelis, N. Weissmann, S. Dimmeler, AM Shah, RP Brandes: Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. In: Circulation research. Volume 110, Number 9, April 2012, pp. 1217-1225, doi : 10.1161 / CIRCRESAHA.112.267054 , PMID 22456182 .
  • K. Schröder, A. Kohnen, A. Aicher, EA Liehn, T. Büchse, S. Stein, C. Weber, S. Dimmeler, RP Brandes: NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells. In: Circulation research. Volume 105, Number 6, September 2009, pp. 537-544, doi : 10.1161 / CIRCRESAHA.109.205138 , PMID 19679834 .

Web links

Individual evidence

  1. ↑ Our team - member Schröder. In: VRC Homepage. Vascular Research Center - Theodor-Stern-Kai 7 - 60596 Frankfurt am Main, accessed on December 12, 2019 (English).
  2. ↑ - Prof'in. Dr. Katrin Schröder Goethe University Frankfurt am Main. Retrieved December 12, 2019 .
  3. ^ German Physiological Society: Du Bois-Reymond Prize. Retrieved January 5, 2020 .
  4. ^ Albert Fraenkel Prize. Accessed January 5, 2020 (German).
  5. ↑ Program for the ACADEMIC CELEBRATION PDF Free Download. Retrieved January 5, 2020 .


personal data
SURNAME Schröder, Katrin
BRIEF DESCRIPTION German biologist and physiologist
DATE OF BIRTH 1975
PLACE OF BIRTH Grevesmühlen