Klimisch score

The Klimisch Score or Klimisch Code is a method for assessing the reliability of toxicological , ecotoxicological and similar studies. It is mainly used in a regulatory context, especially when assessing chemicals in the context of REACH . In IUCLID , fields are provided for the Klimisch score, which the registrants must fill out.

The following scores are possible:

1 = reliable without restrictions
2 = reliable with restrictions
3 = not reliable
4 = cannot be determined

Scores 3 and 4 can only be used in the sense of a weight-of-evidence approach.

The extent to which a result is considered reliable is assessed on the basis of the informative value of the study, the method used, the reporting of the results and the conclusion. Important factors here are a procedure that is as standardized as possible and the description of the experimental procedure and the results.

Individual evidence

↑ H.-J. Klimisch, M. Andreae, U. Tillmann: A Systematic Approach for Evaluating the Quality of Experimental Toxicological and Ecotoxicological Data. In: Regulatory Toxicology and Pharmacology . Volume 25, Number 1, 1997, pp. 1-5, doi: 10.1006 / rtph.1996.1076 , PMID 9056496 .
↑ ECHA : Practical Guide 2: Reporting data using the “evidential value of the data” approach , 2010, ISBN 978-92-9217-025-7 .

[1] H.-J. Klimisch, M. Andreae, U. Tillmann: A Systematic Approach for Evaluating the Quality of Experimental Toxicological and Ecotoxicological Data. In: Regulatory Toxicology and Pharmacology . Volume 25, Number 1, 1997, pp. 1-5, doi: 10.1006 / rtph.1996.1076 , PMID 9056496 .

[2] ECHA : Practical Guide 2: Reporting data using the “evidential value of the data” approach , 2010, ISBN 978-92-9217-025-7 .