Collagenosis
| Classification according to ICD-10 | |
|---|---|
| M30-M36 | System diseases of the connective tissue |
| ICD-10 online (WHO version 2019) | |
With collagenoses ( connective tissue diseases ), more rarely also collagenopathy and collagen disease , it is a question of an inconsistent group of certain autoimmune diseases which, in the case of systemic infestation, predominantly affect connective tissue (histological fibrinoid changes) and blood vessels . In principle, any organ can be affected. Organ-unspecific autoantibodies against cell nucleus material ( antinuclear antibodies ) play a role in the diagnosis . The cause of the collagenosis is still unclear. Many are related to hereditary factors, e.g. B. HLA antigens, hormones (women are more often affected), psychological stress, viruses and sun exposure. It is unclear whether the antinuclear antibodies are the cause, consequence or side effect of the disease. Many collagenoses have similar symptoms, which is why they can often only be distinguished from one another as the disease progresses.
The collagenoses include:
- Systemic lupus erythematosus (SLE)
- Polymyositis and dermatomyositis
- Sjogren's syndrome
- Systemic sclerosis (progressive systemic scleroderma, CREST syndrome)
- Sharp syndrome (so-called mixed collagenosis)
Polyarteritis nodosa and thrombotic-thrombocytopenic purpura are no longer counted among the collagen diseases.
Collagenoses can be treated with immunosuppressive drugs.
literature
- Ludwig Heilmeyer , Wolfgang Müller: The rheumatic diseases. In: Ludwig Heilmeyer (ed.): Textbook of internal medicine. Springer-Verlag, Berlin / Göttingen / Heidelberg 1955; 2nd edition ibid. 1961, pp. 309–351, here: pp. 336–342: Die Kollagenkrankeiten (except for polyarthritis).
