Antinuclear Antibody
The term antinuclear antibody (ANA) or antinuclear factor (ANF) stands for all autoantibodies against antigens in the cell nucleus . The ANA titer , which is usually given, is a value measured in serum. The normal value is ≤ 1: 160, with 3% of healthy people having a titer of 1: 320. In certain diseases that are associated with the destruction of cells, the contents of the cell nucleus enter the blood. The body then makes antibodies that can be detected. In order to be able to further differentiate the cause of the disease, cell nuclei from normal tissue, which have been treated with the ANA, are imaged using immunofluorescence (IFT). The resulting fluorescence pattern indicates certain disease specificities.
An increased ANA value is often an indication of a disease, e.g. B.
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Autoimmune diseases
- from the area of collagenoses
- Systemic Lupus Erythematosus (SLE)
- Polymyositis and dermatomyositis
- Sjogren's syndrome
- CREST syndrome
- Scleroderma
- Sharp syndrome (so-called mixed collagenosis)
- Vasculitis
- chronic autoimmune hepatitis
- from the area of collagenoses
-
rheumatic diseases
- Rheumatoid arthritis (primary rheumatoid arthritis , PCP)
- Lyme disease and some other bacterial infections
Even simple inflammation can add value.
For titers 1:> 80, the pattern and the resulting association with the respective diseases are given, e.g. B. ANA IgG IFT (HEp2) 1: 320 .
literature
- Henryk Dancygier: Clinical Hepatology: Basics, Diagnosis and Therapy of Hepatobiliary Diseases . Springer, Berlin 2003, ISBN 3-540-67559-0 , pp. 220 ff .
- J. David M. Edgar: Immunology: a core text with self-assessment . Elsevier / Churchill Livingstone, Edinburgh 2006, ISBN 0-443-07279-5 , pp. 177 ff .
Web links
- laboratory dictionary: ANA
- Laborlexikon: ANA patterns and possible (ENA) target antigens
