Sharp syndrome
| Classification according to ICD-10 | |
|---|---|
| M35 | Other diseases with systemic involvement of the connective tissue |
| M35.1 | Other overlap syndromes - mixed connective tissue disease (Sharp syndrome) |
| ICD-10 online (WHO version 2019) | |
As mixed connective tissue disease , mixed connective tissue disease or MCTD ( mixed connective tissue disease ) refers to a mild extending collagenosis with a mixture of lupus erythematosus , progressive systemic sclerosis (PSS), polymyositis and rheumatoid arthritis (RA). Antinuclear antibodies (ANA), especially anti-U1-RNP antibodies, can be detected. The disease was first described in 1972 by the American internist Gordon C. Sharp .
literature
- GC Sharp, WS Irvin, EM Tan, RG Gould, HR Holman: Mixed connective tissue disease – an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). In: The American journal of medicine. Volume 52, Number 2, February 1972, pp. 148-159, ISSN 0002-9343 . PMID 4621694 . doi: 10.1016 / 0002-9343 (72) 90064-2
- PJ Venables: Mixed connective tissue disease. In: Lupus. Volume 15, Number 3, 2006, pp. 132-137, ISSN 0961-2033 . PMID 16634365 . (Review).
- M. Aringer, G. Steiner, JS Smolen: Does mixed connective tissue disease exist? Yes. In: Rheumatic diseases clinics of North America. Volume 31, Number 3, August 2005, pp. 411-20, v, ISSN 0889-857X . doi : 10.1016 / j.rdc.2005.04.007 . PMID 16084315 . (Review).
- S1 guideline for mixed collagenosis of the German Society for Child and Adolescent Medicine (DGKJ). In: AWMF online (as of 2013)
- M. Dasbach, M. Bernal-Sprekelsen: Oropharynx carcinoma and Sharp syndrome - in HNO Aktuell-Schnetztor-Verlag Konstanz 1991, ISBN 3-87018-085-4
