LAP2alpha
| LAP2alpha | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 693 amino acids | |
| Isoforms | 3 | |
| Identifier | ||
| Gene name | TMPO | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Mammals | |
LAP2alpha (lamina-associated polypeptide 2alpha) is a protein of the cell nucleus , only in mammalian cells could be detected.
LAP2alpha is one of six splice variants of the LAP2 gene , four of which (LAP2beta, LAP2gamma, LAP2delta and LAP2epsilon) are transmembrane proteins . In amphibians and fish , a further development-specific expressed variant, LAP2omega, could be detected, which is also membrane-bound. LAP2alpha is structurally and functionally distinctly different from the other LAP2 proteins and only shares the N terminus (the first three exons ) with them .
LAP2alpha is localized in the interphase inside the cell nucleus and is a binding partner of A-type lamines . During mitosis , LAP2alpha is specifically phosphorylated and loses its attachment to the chromosomes . Already very early at the end of mitosis, in the early telophase , LAP2alpha is localized again in the area of the core regions on the chromosomes. A characteristic domain of all LAP2 proteins is the LEM domain, which mediates the binding to the DNA-binding protein BAF (Barrier to Autointegration Factor).
Individual evidence
- ↑ Homologues at OMA
- ↑ Dorner D, Gotzmann J, Foisner R: Nucleoplasmic lamins and their interaction partners, LAP2alpha, Rb, and BAF, in transcriptional regulation . In: FEBS J . . 274, No. 6, March 2007, pp. 1362-73. doi : 10.1111 / j.1742-4658.2007.05695.x . PMID 17489094 .