Methuselah Mouse Prize

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The Methuselah Mouse Prize (or Methuselah Mouse Prize , M Prize ) was a competitive award for researchers trying to artificially extend the lifespan of house mice . In doing so, knowledge should also be found about the human aging process . The word is derived from the biblical Methuselah , who was ascribed to old age. Accordingly, a Methuselah mouse is a very old mouse age.

Model organism

description

Research should be funded with the aim of increasing human life expectancy, slowing down aging and combating old-age diseases . Corresponding research fields are gerontology and biogerontology .

The prize was conceived and founded in 2003 by Aubrey de Gray . It was inspired by the Ansari X-Prize and was endowed with over four million US dollars in donations.

Each new longevity record should be awarded according to the formula , where the improvement over the old record is in days and the old record is in days. A doubling of the previous age record would win two thirds of the total prize money. A second prize was intended for researchers who only treated the mice at an advanced age.

Award winners

In June 2013 the record stood at 1,819 days (almost five years) after genetic manipulation. The award winner was a working group led by Andrzej Bartke . The normal life expectancy for the mouse strain used is around three years.

A price for rejuvenation ( rejuvenation ) received Stephen Spindler . In 2009, Z. Dave Sharp received a special award for extending the life of aged mice using rapamycin .

See also

Individual evidence

  1. ↑ The Mprize-. Knowledge Ecology International, accessed October 15, 2016 .
  2. ^ Andrzej Bartke, Holly Brown-Borg: Life Extension in the Dwarf Mouse . In: Current Topics in Developmental Biology . tape 63 , 2004, pp. 189-225 , doi : 10.1016 / s0070-2153 (04) 63006-7 .

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