Mignonac reaction

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In chemistry, the Mignonac reaction is a synthetic method for the production of primary amines 2 . Here are aldehydes 1a (R 1 = organyl radical R 2 or = H) ketone 1b (R 1 R 2 = organyl) in liquid ammonia catalytically hydrogenated.

Mignonac reaction

Absolute ethanol is used as the solvent and nickel as the catalyst .

Atomic economy

An alternative method for the production of primary amines is the Gabriel synthesis , but its atom economy is very poor compared to the Mignonac reaction. In the Mignonac reaction, the only co-product is water. This is why the Mignonac reaction is significantly more economical and resource-saving than the Gabriel synthesis.

Individual evidence

  1. Georges Mignonac: Nouvelle méthode générale de preparation des amines à partir des aldéhydes ou des cétones , Compt. Rend. 1921, 172, pp. 223-226.
  2. ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; S. ONR-62, ISBN 978-0-911910-00-1 .