Mitophagy

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Mitophagy (from ancient Greek μίτος mítos , German 'thread' and ancient Greek φαγεῖν phagein , German 'eat' ) describes a form of autophagocytosis in which mitochondria are specifically broken down by digestive vesicles enveloping mitochondria. These are dismantled and parts of them are put to further use.

Mitophagy can have several triggers:

  • Damage: Damaged mitochondria pose a danger to the cell due to the potential production of oxygen radicals (ROS). These must be eliminated.
  • Aging: Aged mitochondria can be limited in their performance and are potential sources of ROS.
  • Development: As red blood cells mature , the mitochondria are completely degraded.
  • Nutritional deficiency

A mitophagy defect is thought to play a role in Parkinson's disease . Mitophagy occurs, among other things, through the formation of omegasomes .

literature

  • Kim, I. et al . (2007): Selective degradation of mitochondria by mitophagy . In: Arch Biochem Biophys . 462 (2); 245-253; PMID 17475204 ; PMC 2756107 (free full text)
  • H. Abeliovich, M. Zarei, KTG Rigbolt, RJ Youle, J. Dengjel (2013) Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy . In: Nature Communications 4, No. 2789 doi : 10.1038 / ncomms3789

swell

  1. ↑ Rudolf-Werner Dreier (2014): Mitochondria separate garbage . [1]
  2. ↑ a b Richard J. Youle & Derek P. Narendra (2011): Mechanisms of mitophagy . In: Nature Reviews Molecular Cell Biology 12, 9-14; doi : 10.1038 / nrm3028
  3. ↑ YC Wong, EL Holzbaur: Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation. In: Proceedings of the National Academy of Sciences . Volume 111, number 42, October 2014, ISSN  1091-6490 , pp. E4439 – E4448, doi : 10.1073 / pnas.1405752111 . PMID 25294927 , PMC 4210283 (free full text).