Omegasome

An omegasome is a cell compartment of cells that is formed when there is a lack of nutrients and the accompanying autophagy .

properties

Omegasomes consist to a large extent of phosphatidylinositol-3-phosphate and arise from the membrane of the endoplasmic reticulum . The proteins Atg18 and Vmp1 are involved in the formation of omegasomes . The term 'omegasome' is derived from the omega- like (Ω) form. Autophagosomes can develop from omegasomes . When infected with coronaviruses , more omegasomes are formed. The mitophagy partially effected via the formation of omega omen.

literature

DJ Klionsky: Why just eat in, when you can also eat out? In: Autophagy. Volume 9, number 2, February 2013, ISSN 1554-8635 , p. 119, doi: 10.4161 / auto.22915 , PMID 23159909 , PMC 3552876 (free full text).

Individual evidence

^ HE Polson, J. de Lartigue, DJ Rigden, M. Reedijk, S. Urbé, MJ Clague, SA Tooze: Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. In: Autophagy. Volume 6, number 4, May 2010, ISSN 1554-8635 , pp. 506-522, doi: 10.4161 / auto.6.4.11863 , PMID 20505359 .
↑ EL Ax, SA Walker, M. Manifava, P. Chandra, HL Roderick, A. Habermann, G. Griffiths, NT Ktistakis: Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. In: The Journal of Cell Biology . Volume 182, Number 4, August 2008, ISSN 1540-8140 , pp. 685-701, doi: 10.1083 / jcb.200803137 , PMID 18725538 , PMC 2518708 (free full text).
↑ J. Calvo-Garrido, JS King, S. Muñoz-Braceras, R. Escalante: Vmp1 regulates PtdIns3P signaling during autophagosome formation in Dictyostelium discoideum. In: Traffic (Copenhagen, Denmark). Volume 15, number 11, November 2014, ISSN 1600-0854 , pp. 1235-1246, doi: 10.1111 / tra.12210 , PMID 25131297 .
↑ EM Cottam, HJ Maier, M. Manifava, LC Vaux, P. Chandra-Schoenfelder, W. Gerner, P. Britton, NT Ktistakis, T. Wileman: Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate. In: Autophagy. Volume 7, number 11, November 2011, ISSN 1554-8635 , pp. 1335-1347, doi: 10.4161 / auto.7.11.16642 , PMID 21799305 , PMC 3242798 (free full text).
↑ EM Cottam, MC Whelband, T. Wileman: Coronavirus NSP6 restricts autophagosome expansion. In: Autophagy. Volume 10, number 8, August 2014, ISSN 1554-8635 , pp. 1426–1441, doi: 10.4161 / auto.29309 , PMID 24991833 , PMC 4203519 (free full text).
↑ YC Wong, EL Holzbaur: Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation. In: Proceedings of the National Academy of Sciences of the United States of America . Volume 111, number 42, October 2014, ISSN 1091-6490 , pp. E4439 – E4448, doi: 10.1073 / pnas.1405752111 , PMID 25294927 , PMC 4210283 (free full text).

[1] HE Polson, J. de Lartigue, DJ Rigden, M. Reedijk, S. Urbé, MJ Clague, SA Tooze: Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. In: Autophagy. Volume 6, number 4, May 2010, ISSN 1554-8635 , pp. 506-522, doi: 10.4161 / auto.6.4.11863 , PMID 20505359 .

[axe-2] EL Ax, SA Walker, M. Manifava, P. Chandra, HL Roderick, A. Habermann, G. Griffiths, NT Ktistakis: Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. In: The Journal of Cell Biology . Volume 182, Number 4, August 2008, ISSN 1540-8140 , pp. 685-701, doi: 10.1083 / jcb.200803137 , PMID 18725538 , PMC 2518708 (free full text).

[3] J. Calvo-Garrido, JS King, S. Muñoz-Braceras, R. Escalante: Vmp1 regulates PtdIns3P signaling during autophagosome formation in Dictyostelium discoideum. In: Traffic (Copenhagen, Denmark). Volume 15, number 11, November 2014, ISSN 1600-0854 , pp. 1235-1246, doi: 10.1111 / tra.12210 , PMID 25131297 .

[4] EM Cottam, HJ Maier, M. Manifava, LC Vaux, P. Chandra-Schoenfelder, W. Gerner, P. Britton, NT Ktistakis, T. Wileman: Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate. In: Autophagy. Volume 7, number 11, November 2011, ISSN 1554-8635 , pp. 1335-1347, doi: 10.4161 / auto.7.11.16642 , PMID 21799305 , PMC 3242798 (free full text).

[5] EM Cottam, MC Whelband, T. Wileman: Coronavirus NSP6 restricts autophagosome expansion. In: Autophagy. Volume 10, number 8, August 2014, ISSN 1554-8635 , pp. 1426–1441, doi: 10.4161 / auto.29309 , PMID 24991833 , PMC 4203519 (free full text).

[6] YC Wong, EL Holzbaur: Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation. In: Proceedings of the National Academy of Sciences of the United States of America . Volume 111, number 42, October 2014, ISSN 1091-6490 , pp. E4439 – E4448, doi: 10.1073 / pnas.1405752111 , PMID 25294927 , PMC 4210283 (free full text).