Monobactams

Monobactams with the β-lactam ring marked blue

Aztreonam

Tigemonam

Monobactams ( e.g. aztreonam and tigemonam) are drugs that are used as antibiotics .

Manufacturing and structure

Monobactams are semi-synthetic antibiotics. They are produced by gram-negative bacteria and then synthetically modified. Like many other β- lactam antibiotics, they contain a monocyclic β-lactam ring but no further fused-on ring.

application

Monobactams are β-lactamase -stable, but are cleaved by Extended Spectrum β-lactamases (ESBL). They are not absorbed from the gastrointestinal tract and must therefore be administered parenterally . Their spectrum of activity includes only gram-negative pathogens. They show no effect on anaerobic and gram-positive germs. Their therapeutic application is mostly on individuals with penicillin - and cephalosporin - allergy limited.

Individual evidence

1. ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 156, ISBN 978-0-911910-00-1 .

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