Neddylation

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The neddylation (in plants and yeast synonymous Related to ubiquitin , RUB ) is a post-translational modification of proteins .

properties

Neddylation takes place by modifying a protein with Nedd8 ( English neural-precursor-cell-expressed developmentally down-regulated 8 'neural precursor cells-expressed and down-regulated in development', 76 amino acids ), analogous to ubiquitination . Neddylation takes place via an isopeptide bond on the carboxy group of the C -terminal glycine of Nedd8 to the ε- amino group of a lysine in the target protein. MLN4924 is an inhibitor of neddylation.

Neddylation is involved in various cellular processes, e.g. B. in the regulation of the ubiquitin proteasome system , in the transcription and in cell contacts .

Incorrect neddylation is implicated in cancer , neurodegenerative diseases, and heart disease, among other things .

Individual evidence

  1. ↑ J. Mergner, C. Schwechheimer: The NEDD8 modification pathway in plants. In: Frontiers in plant science. Volume 5, 2014, p. 103, doi : 10.3389 / fpls.2014.00103 , PMID 24711811 , PMC 3968751 (free full text).
  2. ↑ ST Nawrocki, P. Griffin, KR Kelly, JS Carew: MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy. In: Expert opinion on investigational drugs. Volume 21, Number 10, October 2012, pp. 1563-1573, doi : 10.1517 / 13543784.2012.707192 , PMID 22799561 .
  3. ↑ a b S. Kandala, IM Kim, H. Su: Neddylation and deneddylation in cardiac biology. In: American journal of cardiovascular disease. Volume 4, number 4, 2014, pp. 140-158, PMID 25628956 , PMC 4299693 (free full text).
  4. ^ Y. Chen, RL Neve, H. Liu: Neddylation dysfunction in Alzheimer's disease. In: Journal of cellular and molecular medicine. Volume 16, number 11, November 2012, pp. 2583-2591, doi : 10.1111 / j.1582-4934.2012.01604.x , PMID 22805479 , PMC 3484225 (free full text).