Neovascularization

Neovascularization ( neovascularization , neovascularization , NV) refers to all processes in the formation of new vessels in the adult organism. In medical parlance, the term is often used in connection with the process of excessive or uncontrolled formation of new vessels or vascular growth. However, neovascularization also denotes non-pathological processes in the formation of new vessels, for example in transplant medicine and in wound healing .

Development and treatment of pathological neovascularization

Neovascularization is associated with a local overproduction of the vascular endothelial growth factor (VEGF), which tumor cells increasingly release in the course of the progression of cancer in order to supply the growing and spreading tumor with sufficient blood and thus with oxygen and nutrients. With medication it is possible to slow down or even stop these processes and thus to make a tumor reduction with subsequent removal possible or to extend progression-free survival .

When wearing contact lenses , neovascularization in the cornea can occur if the contact lenses permanently obstruct the oxygen supply to the cornea. An ophthalmologist can detect this new vessel formation during an external examination with a slit lamp . Treatment options include exposure to contact lenses, topical medication with steroids, or GS-101 (an antisense oligonucleotide ) drops.

List of diseases

numerous tumor diseases
exudative “wet” macular degeneration
Diabetic retinopathy (proliferative retinopathy)
Neovascularization glaucoma
Neovascularization in the cornea triggered by contact lenses
Neovascularization i. R. a retinopathia prematurorum
Macular Telangiectasia (MacTel)

Individual evidence

^ Angiogenesis - freely available from NCBI Thomas H. Adair and Jean-Pierre Montani, Morgan & Claypool Life Sciences, 2010.
^ Plastic Surgery: Head and Neck, Alfred Berger and Robert Hierner, Springer, 2004
^ AG Beule, W. Hosemann: [Wound healing after endoscopic sinus surgery and postoperative management]. In: ENT. Volume 57, Number 8, August 2009, pp. 763-771, ISSN 1433-0458 . doi : 10.1007 / s00106-009-1938-8 . PMID 19609734 . (Review).
↑ Drug Therapy Eye 5th Edition, Carl Erb and Torsten Schlote, Thieme, 2011
↑ C. Cursiefen, F. Bock, FK Horn, FE Kruse, B. Seitz, V. Borderie, B. Früh, MA Thiel, F. Wilhelm, B. Geudelin, I. Descohand, KP Steuhl, A. Hahn, D Meller: GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial. In: Ophthalmology. Volume 116, Number 9, September 2009, pp. 1630-1637, ISSN 1549-4713 . doi : 10.1016 / j.ophtha.2009.04.016 . PMID 19643487 .

[1] Angiogenesis - freely available from NCBI Thomas H. Adair and Jean-Pierre Montani, Morgan & Claypool Life Sciences, 2010.

[2] Plastic Surgery: Head and Neck, Alfred Berger and Robert Hierner, Springer, 2004

[PMID19609734-3] AG Beule, W. Hosemann: [Wound healing after endoscopic sinus surgery and postoperative management]. In: ENT. Volume 57, Number 8, August 2009, pp. 763-771, ISSN 1433-0458 . doi : 10.1007 / s00106-009-1938-8 . PMID 19609734 . (Review).

[4] Drug Therapy Eye 5th Edition, Carl Erb and Torsten Schlote, Thieme, 2011

[PMID19643487-5] C. Cursiefen, F. Bock, FK Horn, FE Kruse, B. Seitz, V. Borderie, B. Früh, MA Thiel, F. Wilhelm, B. Geudelin, I. Descohand, KP Steuhl, A. Hahn, D Meller: GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial. In: Ophthalmology. Volume 116, Number 9, September 2009, pp. 1630-1637, ISSN 1549-4713 . doi : 10.1016 / j.ophtha.2009.04.016 . PMID 19643487 .