Nucleus basalis

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The nucleus basalis (Meynert, Ch4) is one of the most important acetylcholine- producing nuclei in the central nervous system . It is located in the frontal, basal telencephalon between the amygdala and globus pallidus . The nucleus basalis sends efferents to the limbic system and the entire cerebral cortex . The nucleus was first described by the neuroanatomist Theodor Meynert .

Failures of the basal nucleus are associated with Alzheimer's disease and result from the absence of the transmitter acetylcholine in the telencephalon. For the treatment of Alzheimer's dementia, acetylcholinesterase inhibitors are used to increase the concentration of acetylcholine in the synaptic cleft .

literature

  • Mathias Berger: Mental Illnesses: Clinic and Therapy . Urban & Fischer, 2004, ISBN 3-437-22480-8 .